Examining the link between sleep and cognitive performance in older adults
Cross-sectional Investigation of Sleep Apnea and Cognition in Older Adults Using the ANNE Vital Sign System
This study is testing how different aspects of sleep affect memory and thinking skills in older adults using a wearable device to track their sleep.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 55 Years to 85 Years |
| Sex | All |
| Sponsor | Sunnybrook Health Sciences Centre Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT06423118 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between various sleep parameters, such as respiratory events and the apnea-hypopnea index, and cognitive performance in older adults. Participants will wear the ANNE Vital Sign System for 24 hours to collect sleep data and will complete cognitive tests to assess memory and thinking abilities. The study seeks to address the gap in understanding how objectively measured sleep quality impacts cognitive function, particularly in the aging population. By utilizing wearable technology, the study aims to provide a more accessible method for monitoring sleep compared to traditional polysomnography.
Who should consider this trial
Good fit: Ideal candidates are older adults aged 55-85 who are cognitively intact and capable of participating in cognitive assessments.
Not a fit: Patients with significant cognitive impairment, dementia, or unstable medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of sleep-related issues that affect cognitive health in older adults.
How similar studies have performed: While there is accumulating evidence linking sleep quality to cognitive impairment, this specific approach using wearable technology in older adults is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Sufficient knowledge of English to understand and provide informed consent 2. Competent to provide consent 3. Aged 55-85, Male and Female 4. ≥ 8 years of education 5. Capable of cooperating for the duration of the study procedures and assessments 6. No frank cognitive impairment or dementia 7. Sufficient (corrected) vision to participate in cognitive testing 8. Sufficient (corrected) hearing to participate in cognitive testing Exclusion Criteria: 1. Cannot read and comprehend English language instructions 2. Major cardio- or cerebro-vascular event (heart attack, stroke, significant white matter changes) 3. Unstable diseases (e.g., pulmonary, endocrine disorder) 4. Active malignancy or infectious diseases 5. History of significant learning disability 6. Major psychiatric/neurologic/degenerative disorder, including a diagnosis of mild cognitive impairment or dementia 7. History of significant head trauma or recurrent concussions requiring hospitalization followed by persistent neurologic defaults or known structural brain abnormalities 8. Pain or sleep disorder that could interfere with cognitive testing 9. Major medical concerns that might interfere with cognitive testing 10. Recent history of substance/drug abuse 11. Known nickel allergy 12. Known cardiac implantable device 13. Known arrhythmias 14. Outside the included age range 15. Pregnant or breast feeding 16. Otherwise unable to use the ANNE sensors; for example, finger amputations.
Where this trial is running
Toronto, Ontario
- Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Jennifer Rabin, PhD — Sunnybrook Research Institute
- Study coordinator: Alexander Nyman, BSc
- Email: alexander.nyman@sri.utoronto.ca
- Phone: 416-480-6100
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.