Rhythmic Initiation vs Isometric Training for Arm Recovery After Stroke
Official title: Comparative Effects of Rhythmic Initiation and Isometric Resistance Training on Upper Limb Motor Function, Strength, and Coordination in Subacute Stroke Patients
Run by University of Faisalabad · NCT07598435 · Data updated 2026-11-12
This trial tests whether Rhythmic Initiation or Isometric Resistance Training helps improve upper-limb function in people who recently had a first stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 60 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University of Faisalabad Academic / other |
| Locations | 1 site (Faisalābad, Punjab Province) |
| Status | Recruiting |
| Started | January 19, 2026 |
| Main results expected | May 19, 2026 |
| Study ends | June 24, 2026 |
| Registry record updated | June 3, 2026 |
| Trial ID | NCT07598435 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 40–60 with a first-time subacute unilateral upper-limb stroke (1–6 months) and sufficient ability to participate in physical therapy.
✕Probably not a fit
Patients with severe spasticity (Modified Ashworth >3), recurrent or bilateral stroke, or significant shoulder conditions may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this single-blind, parallel-arm study, adults aged 40–60 with a new subacute stroke and unilateral arm weakness are randomized to receive either Rhythmic Initiation (a PNF-based, progressive movement therapy) or Isometric Resistance Training for 30 minutes per session, five days a week for four weeks. Participants are recruited from the University of Faisalabad in Pakistan and allocated 1:1 to the two therapies; outcome assessors are blinded to treatment. The trial focuses on restoring motor control and strength in the affected upper limb using structured, therapist-guided exercises. Eligible individuals must have subacute stroke (1–6 months post-onset), no severe spasticity or contraindicating conditions, and be able to participate in therapy. The primary aim is to compare the two approaches for improving upper-limb motor function in this population.
Why it matters
Potential benefit: If successful, the study could identify a more effective therapy for improving arm strength and control after subacute stroke.
How similar studies have gone: Prior rehabilitation approaches using PNF or isometric training have shown potential benefits, but direct comparison in this specific subacute window is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinically diagnosed subacute stroke (1 to 6 months post-onset) * Unilateral upper limb involvement * Age 40 to 60 years * Both genders * Medically stable and able to participate in physical therapy * Able to provide informed consent Exclusion Criteria: * Severe spasticity (Modified Ashworth Scale score \>3) * Recurrent or bilateral stroke * Shoulder subluxation * Shoulder or upper limb pain limiting active movement * Cognitive or perceptual deficits impairing ability to follow instructions * Other neurological disorder affecting upper limb (e.g., Parkinson's disease, multiple sclerosis) * Orthopedic condition affecting upper limb function
Where it's running
-
The University of Faisalabad
Faisalābad, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Dr Marium Zafar, MS-NMPT
- Email: mariumzafar.dpt@tuf.edu.pk
- Phone: +92 300 4561972
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.