Using Brain-Computer Interfaces for Arm Rehabilitation After Stroke
Official title: Application of Functional Electrical Stimulation Therapy Coupled to a P300-based Brain-Computer Interface for Paretic Upper Limb Rehabilitation in Chronic Stroke: A Randomized Controlled Trial
Run by Instituto Nacional de Rehabilitacion · NCT06409754 · Data updated 2026-11-12
This study is testing a new therapy that uses a brain-computer interface to help stroke survivors improve their arm movement during rehabilitation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 26 (estimated) |
| Sponsor | Instituto Nacional de Rehabilitacion Government |
| Locations | 1 site (Mexico City, Mexico City) |
| Status | Recruiting |
| Started | August 6, 2024 |
| Main results expected | July 2025 |
| Study ends | June 2026 |
| Registry record updated | February 27, 2025 |
| Trial ID | NCT06409754 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have experienced a stroke at least six months prior and have moderate to severe upper limb paralysis.
✕Probably not a fit
Patients with other neurological disorders, severe cognitive deficits, or those who have had multiple strokes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research evaluates the effectiveness of a new therapy combining functional electrical stimulation with a Brain-Computer Interface (BCI) for improving arm movement in patients recovering from a stroke. Participants will be divided into two groups: one receiving standard physical therapy and the other receiving both standard therapy and the BCI-FES intervention. The BCI system interprets the user's intentions to assist in executing hand movements during rehabilitation sessions. The study aims to determine if this innovative approach can enhance motor recovery compared to conventional methods alone.
Why it matters
Potential benefit: If successful, this therapy could significantly improve motor recovery and daily functioning for stroke survivors with upper limb paralysis.
How similar studies have gone: Previous studies have shown promise in using brain-computer interfaces for rehabilitation, indicating potential for success in this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with ischemic or hemorrhagic stroke (evidenced by CT or MRI) * ≥6 months from stroke onset, chronic phase * Unilateral lesion * Age ≥18 years * Moderate-severe hemiparesis (FMA-UE: ≤45) * Full passive ranges of motion in the elbow, forearm, wrist, and hand * Minimal cognitive level necessary to follow instructions and complete tasks * Desire to participate in the study Exclusion Criteria: * Neurological disorders (Parkinsons disease, epilepsy, dementia) * Neurological or musculoskeletal condition directly affecting the upper limb (dystonia, severe spasticity -muscle tone for elbow, wrist and fingers \> 3 according to modified Ashworth scale-) * Contraindications for MRI (implantable devices -pacemakers-, claustrophobia, others) * Cognitive deficit (MoCA \<20 points) * Severe aphasia * Severe psychiatric disorders * More than one stroke
Where it's running
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Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra
Mexico City, Mexico City, Mexico Recruiting
Study contacts
- Study coordinator: Jimena Quinzaños Fresnedo, MD, PhD
- Email: jquinzanos@inr.gob.mx
- Phone: +52 5559991000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
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Rhythmic Initiation vs Isometric Training for Arm Recovery After Stroke
This trial tests whether Rhythmic Initiation or Isometric Resistance Training helps improve upper-limb function in people who recently had a first stroke.
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Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
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Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
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Using virtual reality for rehabilitation after stroke
This study tests whether using virtual reality games can help people recovering from a stroke improve their arm and hand movement better than regular rehab methods.
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Combining brain stimulation with therapy to improve hand movement after stroke
This study is testing whether different types of brain stimulation combined with therapy can help stroke survivors improve their hand movement.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.