vNOTES versus laparoscopic salpingectomy for ectopic pregnancy
Comparison of vNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) Salpingectomy and Laparoscopic Salpingectomy Performed for Ectopic Pregnancy
This trial tests whether vNOTES or conventional laparoscopic salpingectomy gives faster recovery, less postoperative pain, and similar safety for women aged 18–55 who need surgery for ectopic pregnancy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 56 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | Female |
| Sponsor | Gaziosmanpasa Research and Education Hospital Government |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07057115 on ClinicalTrials.gov |
What this trial studies
The trial compares two surgical approaches—vaginal natural orifice transluminal endoscopic surgery (vNOTES) salpingectomy and conventional laparoscopic salpingectomy—in women diagnosed with ectopic pregnancy who require operative management. Eligible and consenting participants will undergo one of the two procedures and be followed for outcomes such as operative time, postoperative pain scores, complication rates, hospital stay length, and time to recovery. The study is designed to test the feasibility, safety, and effectiveness of vNOTES as an alternative minimally invasive technique to standard laparoscopy. Standardized perioperative care and outcome measures will be used to enable direct comparison between the groups.
Who should consider this trial
Good fit: Women aged 18–55 diagnosed with ectopic pregnancy who are not candidates for medical treatment and who are medically fit for surgery without contraindicating systemic disease would be appropriate participants.
Not a fit: People whose ectopic pregnancy can be treated medically, or who have advanced pelvic infection, significant pelvic anatomical abnormalities, immunodeficiency, or other systemic conditions that make surgery unsafe, are unlikely to benefit from this trial.
Why it matters
Potential benefit: If successful, vNOTES could reduce postoperative pain and shorten hospital stay and recovery time compared with standard laparoscopy.
How similar studies have performed: vNOTES has shown promising results in other gynecologic procedures for reduced pain and quicker recovery, but randomized data specifically for ectopic pregnancy are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Women diagnosed with ectopic pregnancy Without heterotopic pregnancy Women aged 18-55 years, within reproductive age Patients for whom medical treatment is not appropriate Patients requiring surgical intervention Patients without systemic diseases that may contraindicate surgery Patients who have signed and approved the informed consent form to participate in the study Exclusion Criteria: Ectopic pregnancy cases that can be treated with medical therapy Patients with advanced pelvic infections or pelvic anatomical abnormalities Patients with immunodeficiency or systemic diseases that contraindicate surgery
Where this trial is running
Istanbul
- Gaziosmanpaşa Training and Research Hospital — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: havva betül bacak, md — Gaziosmanpaşa training and research hospital
- Study coordinator: yağmur aciyiyen, md
- Email: yagmuraciyiyen@gmail.com
- Phone: +90 5425669593
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.