Methotrexate for ectopic pregnancy in patients with relative contraindications
Official title: A Retrospective Evaluation of the Effectiveness of Methotrexate Treatment in Cases of Ectopic Pregnancy With Relative Contraindications
Run by Bagcilar Training and Research Hospital · NCT07186127 · Data updated 2026-11-12
This review will see if methotrexate worked safely and effectively for women with ectopic pregnancy who had conditions that make the drug relatively risky.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 48 Years |
| Sex | Women only |
| Enrollment | 230 (estimated) |
| Sponsor | Bagcilar Training and Research Hospital Government |
| Drugs / interventions | methotrexate |
| Locations | 1 site (Istanbul, Türkiye) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | September 30, 2025 |
| Study ends | May 1, 2026 |
| Registry record updated | September 22, 2025 |
| Trial ID | NCT07186127 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women diagnosed with ectopic pregnancy who received systemic methotrexate at the institution and have complete follow-up records, including those with documented relative contraindications, are the focus of this analysis.
✕Probably not a fit
Patients with absolute contraindications to methotrexate, severe organ failure, or incomplete medical records are not represented and are unlikely to benefit from the study's conclusions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This retrospective observational analysis will examine medical records of 238 patients diagnosed with ectopic pregnancy and treated with methotrexate at Bagcilar Training and Research Hospital between 2019 and 2024. Investigators will identify which patients had relative contraindications (for example, mild renal or hepatic impairment), record methotrexate dosing and administration route, and document treatment response, need for surgery, and complications. Outcomes in the subgroup with relative contraindications will be compared with the broader treated population to identify factors associated with success or failure. No new interventions are performed; the work uses existing clinical data from a single-center cohort.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify which patients with relative contraindications can safely avoid surgery and receive methotrexate instead.
How similar studies have gone: Prior studies support methotrexate for selected ectopic pregnancies, but specific evidence about use in patients with relative contraindications is limited and inconsistent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with ectopic pregnancy * Received methotrexate (MTX) treatment * Underwent surgical treatment due to lack of response to MTX therapy * Compliant with treatment follow-up Exclusion Criteria: * Participants with contraindications to methotrexate (MTX) treatment * Participants non-compliant with follow-up
Where it's running
-
University of Health Sciences, Training and Research Hospital
Istanbul, Türkiye, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: gülhan özüm, md — Sağlık Bilimleri Üniversitesi, Bağcılar Eğitim ve Araştırma Hastanesi
- Study coordinator: gülhan özüm, md
- Email: gulhanozum86@gmail.com
- Phone: +905355784928
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.