Clinical trial Recruiting at 1 site Observational Ages 18 to 45 Women only

Doppler ultrasound to predict success of conservative or methotrexate treatment for tubal ectopic pregnancy

Official title: Doppler Flow in Tubal Ectopic Pregnancy in Diagnosis as a Predictor of Treatment Success - Conservative and MTX Treatment

Run by Meir Medical Center · NCT07541937 · Data updated 2026-11-12

This project will test whether specific Doppler blood-flow measurements at diagnosis can help predict if conservative management or methotrexate will successfully treat tubal ectopic pregnancy.

More Ectopic Pregnancy trials

Quick facts

Study typeObservational
Ages18 Years to 45 Years
SexWomen only
Enrollment60 (estimated)
SponsorMeir Medical Center
Academic / other
Drugs / interventionsmethotrexate
Locations1 site (Kfar Saba, Israel)
StatusRecruiting
StartedJune 1, 2024
Main results expectedJune 1, 2027
Study endsJune 1, 2027
Registry record updatedApril 21, 2026
Trial IDNCT07541937 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women aged 18–45 with a confirmed tubal ectopic pregnancy who are hemodynamically stable and eligible for conservative management or methotrexate therapy are ideal candidates.

Probably not a fit

Patients who are hemodynamically unstable, have suspected tubal rupture, non-tubal ectopic pregnancies, or require immediate surgery are unlikely to benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective study enrolling about 60 women with hemodynamically stable tubal ectopic pregnancies at diagnosis. Investigators will record Doppler ultrasound parameters (resistive index, pulsatility index, and peak systolic velocity) and clinical/laboratory data, then follow patients treated according to standard departmental protocols (conservative monitoring or methotrexate). The primary aim is to see whether Doppler measures at presentation predict treatment success; secondary aims include exploring other factors such as gestational features, pain, bleeding, and beta-hCG levels. Results could clarify whether Doppler vascularization should inform selection of non-surgical management.

Why it matters

Potential benefit: If successful, clinicians could more accurately select patients for conservative or methotrexate therapy, potentially reducing failed medical treatment and the need for surgery.

How similar studies have gone: Previous smaller studies have suggested a link between Doppler vascularization and treatment outcomes, but findings are mixed and there is no widely accepted threshold yet.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria:

* Tubal ectopic pregnancy
* Hemodynamically stable, with no suspicion of rupture,
* Eligible for MTX or conservative therapy.

Exclusion criteria:

* Intrauterine pregnancy
* Hemodynamic instability
* Suspected tubal rupture
* Other ectopic pregnancy: CSP, Ovarian, heterotopic pregnancy

Where it's running

  • Meir Medical Center
    Kfar Saba, Israel, Israel
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.