Doppler ultrasound to predict success of conservative or methotrexate treatment for tubal ectopic pregnancy
Doppler Flow in Tubal Ectopic Pregnancy in Diagnosis as a Predictor of Treatment Success - Conservative and MTX Treatment
Meir Medical Center · NCT07541937
This project will test whether specific Doppler blood-flow measurements at diagnosis can help predict if conservative management or methotrexate will successfully treat tubal ectopic pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Meir Medical Center (other) |
| Drugs / interventions | methotrexate |
| Locations | 1 site (Kfar Saba, Israel) |
| Trial ID | NCT07541937 on ClinicalTrials.gov |
What this trial studies
This is a prospective study enrolling about 60 women with hemodynamically stable tubal ectopic pregnancies at diagnosis. Investigators will record Doppler ultrasound parameters (resistive index, pulsatility index, and peak systolic velocity) and clinical/laboratory data, then follow patients treated according to standard departmental protocols (conservative monitoring or methotrexate). The primary aim is to see whether Doppler measures at presentation predict treatment success; secondary aims include exploring other factors such as gestational features, pain, bleeding, and beta-hCG levels. Results could clarify whether Doppler vascularization should inform selection of non-surgical management.
Who should consider this trial
Good fit: Women aged 18–45 with a confirmed tubal ectopic pregnancy who are hemodynamically stable and eligible for conservative management or methotrexate therapy are ideal candidates.
Not a fit: Patients who are hemodynamically unstable, have suspected tubal rupture, non-tubal ectopic pregnancies, or require immediate surgery are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, clinicians could more accurately select patients for conservative or methotrexate therapy, potentially reducing failed medical treatment and the need for surgery.
How similar studies have performed: Previous smaller studies have suggested a link between Doppler vascularization and treatment outcomes, but findings are mixed and there is no widely accepted threshold yet.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Tubal ectopic pregnancy * Hemodynamically stable, with no suspicion of rupture, * Eligible for MTX or conservative therapy. Exclusion criteria: * Intrauterine pregnancy * Hemodynamic instability * Suspected tubal rupture * Other ectopic pregnancy: CSP, Ovarian, heterotopic pregnancy
Where this trial is running
Kfar Saba, Israel
- Meir Medical Center — Kfar Saba, Israel, Israel (RECRUITING)
Study contacts
- Study coordinator: Chen Manor Bar, MD
- Email: manor.chen@gmail.com
- Phone: +972544414211
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Ectopic Pregnancy, ectopic pregnancy conservative management, Ectopic pregnancy MTX therapy, Doppler flow parameters in ectopic pregnancy