Vascular light therapy to help blood pressure in people on losartan
Official title: Effect of Vascular Photobiomodulation on Cardiovascular Parameters of Treated Hypertensive Patients: A Randomized and Controlled Clinical Trial
Run by University of Nove de Julho · NCT07525310 · Data updated 2026-11-12
This study tests whether a red laser treatment around the wrist can help lower blood pressure and improve blood vessel function in adults taking losartan for hypertension.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Nove de Julho Academic / other |
| Locations | 1 site (São Paulo, São Paulo) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | August 31, 2027 |
| Study ends | November 30, 2027 |
| Registry record updated | September 9, 2026 |
| Trial ID | NCT07525310 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-65 with hypertension controlled on losartan (100 mg/day) for 2–24 months.
✕Probably not a fit
Patients not responding to losartan or with unstable blood pressure or comorbidities may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a double-blind, randomized, sham-controlled interventional trial enrolling 80 adults with hypertension who are on losartan. Participants will receive either active vascular photobiomodulation or a sham procedure over 4 weeks, with two 30-minute sessions each week. The study measures changes in office and home blood pressure, as well as vascular function via brachial artery flow-mediated dilation. Blinding is maintained for participants and outcome assessors, and only the device technician knows group assignment. Assessments are performed around the first and last sessions to capture acute and chronic effects.
Why it matters
Potential benefit: If successful, the therapy could offer an additional method to help manage blood pressure and improve vascular function in hypertensive patients already taking losartan.
How similar studies have gone: Previous studies in vascular photobiomodulation have shown signals of vascular effects, but robust clinical benefits in hypertension remain exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be taking losartan at a dose of 100 mg/day, either as monotherapy or in combination with other antihypertensive medications, administered in two divided doses, for a minimum of 2 months and a maximum of 24 months. * Present systolic blood pressure is less than or equal to 140 mmHg and diastolic less than or equal to 90 mmHg. * Not having used any other antihypertensive medication in the last 2 months. * Age between 18 and 65 years * If female, not pregnant * No cutaneous/subcutaneous lesions on both arms. * No musculoskeletal, rheumatic, cardiovascular, metabolic, neurological, oncological, immunological, hematological, psychiatric or cognitive diagnoses and that may be worsened by the intervention or prevent the correct application of FBM vascular. Exclusion Criteria: * Changes in medication status during the study
Where it's running
-
Raphael Dias
São Paulo, São Paulo, Brazil Recruiting
Study contacts
- Principal investigator: Raphael Dias, PhD — University of Nove de Julho
- Study coordinator: Celso Muniz, MD
- Email: freitas_celso@uol.com.br
- Phone: +55 11 98369-6696
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.