Using total lymphoid irradiation for pediatric stem cell transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares pediatric patients undergoing haploidentical hematopoietic stem cell transplantation (HSCT) who receive total lymphoid irradiation (TLI) with age- and disease-matched controls receiving conventional total body irradiation (TBI). Participants will receive TLI via tomotherapy, delivering a total dose of 6Gy over two days, while the control group will have received TBI at varying doses. The study aims to evaluate outcomes such as graft failure-free survival, graft-versus-host disease (GVHD)-free survival, overall survival, and adverse effects. The goal is to determine the effectiveness and safety of TLI as a conditioning treatment in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 0-18 years who requires allogeneic HSCT, has no human leukocyte antigen (HLA)-matched sibling donor but has an HLA-haploidentical donor.
* Adequate organ function to tolerate the conditioning chemotherapy and radiotherapy
* Karnofsky or Lansky performance status score ≥50

Exclusion Criteria:

* Pregnant or lactating woman
* HIV infection
* Patients for whom alternative treatment is deemed more appropriate by treating physician
* Patients who are unlikely to benefit from haploidentical hematopoietic stem cell transplantation, e.g., terminal malignancy with multiorgan failure

Where it's running

• Hong Kong Children's Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Daniel Cheuk — Hong Kong Children's Hospital
• Study coordinator: Daniel Cheuk
• Email: cheukkld@gmail.com
• Phone: 852-35136049

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.