Infusion of specialized donor lymphocytes after stem cell transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of CD62L depleted donor lymphocyte infusion in conjunction with T cell depleted haploidentical hematopoietic stem cell transplantation to treat patients with various malignant or non-malignant diseases. The study aims to assess the effectiveness of this approach by evaluating graft failure-free and graft-versus-host disease-free survival rates at one year, as well as monitoring adverse events and post-transplant complications. The trial involves the collection of stem cells from a related haploidentical donor, which are then processed to remove specific T cells before being infused into the patient on the same day.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient who requires allogeneic hematopoietic stem cell transplant, has no human leukocyte antigen (HLA)-matched sibling donor but has an HLA-haploidentical donor.
* Adequate organ function to tolerate the conditioning chemotherapy and radiotherapy
* Karnofsky or Lansky performance status score ≥50

Exclusion Criteria:

* Pregnant or lactating woman
* HIV infection
* Patients for whom alternative treatment is deemed more appropriate by treating physician
* Patients who are unlikely to benefit from haploidentical hematopoietic stem cell transplantation, e.g., terminal malignancy with multiorgan failure

Where it's running

• Hong Kong Children's Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Daniel Cheuk — Hong Kong Children's Hospital
• Study coordinator: Daniel Cheuk
• Email: cheukkld@gmail.com
• Phone: 85235136049

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.