Using remote ischemic conditioning to improve outcomes for patients undergoing off-pump coronary artery bypass grafting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effects of remote ischemic conditioning (RIC) on patients diagnosed with coronary artery disease who are scheduled for off-pump coronary artery bypass grafting (CABG). A total of 648 participants will be enrolled across five centers in China, with patients randomly assigned to either the RIC group or a control group. The primary outcome measured will be the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) within three months post-surgery. The study aims to determine if RIC can enhance short-term prognosis by reducing ischemia-reperfusion injury.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with coronary artery disease and require off-pump CABG surgery.
* Between 18 and 75 years old;
* Normal left ventricular systolic function (ejection fraction \>40%) and left ventricular end-diastolic internal diameter (\<60 mm) in the cardiac ultrasound tests;
* No or mild heart valve and great vessel abnormalities which do not require surgical intervention;
* Participants or their authorized relatives agree to participate in the clinical trial and sign the informed consent.

Exclusion Criteria:

* Severe tissue injuries.
* Myalgia, fractures and other peripheral vascular lesions.
* Bypass graft being the radial artery.
* Stenosis or severe malformations of the subclavian, jugular and femoral arteries and veins.
* Previous vagus nerve trunk dissection or vagus nerve block surgery.
* Other surgical operations at the same time.
* Patients with pre-existing severe cardiac insufficiency, acute coronary syndromes, malignant hypertension and cardiogenic shock.
* Severe coagulation abnormality or severe anemia.
* Severe mental disorder.
* Malignant tumors.
* Pregnant or lactating.
* Increased risk of treatment for patients, according to investigators.
* Refuse to sign the informed consent form.

Where it's running

• First Affiliated Hospital of Xi'an Jiantong University
  Xi'an, Shaanxi, China Recruiting

Study contacts

• Principal investigator: Yang Yan — First Affiliated Hospital Xi'an Jiaotong University
• Study coordinator: Yang Yan
• Email: yangyan3@xjtu.edu.cn
• Phone: +86.29.85323869

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.