Desflurane versus propofol anesthesia for coronary artery bypass surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3, multicenter randomized interventional trial compares desflurane-based inhaled anesthesia with propofol-based total intravenous anesthesia in adults undergoing elective CABG. Participants are adults scheduled for isolated CABG who meet inclusion criteria and do not have recent MI, combined valve/aortic procedures, or severe organ dysfunction. The primary outcome is the incidence of severe postoperative major cardiac events and other perioperative complications, with standardized perioperative management across sites. The study is being run at multiple hospitals in China to capture real-world surgical populations and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled for elective coronary artery bypass grafting (CABG)
2. Age ≥ 18 years old;
3. Sign the informed consent form.

Exclusion Criteria:

1. Emergency or urgent operation
2. Concomitant valve or aortic surgery
3. History of myocardial infarction in recent 30 days
4. Current use of myocardial preconditioning-affecting medications, such as sulfonylurea (glibenclamide), allopurinol, theophylline, nicorandil(last dose \< 8 hrs), etc
5. Participated in other randomized controlled clinical trials in recent 3 months
6. General anesthesia in recent 30 days
7. History of kidney and liver transplantation, or severe liver and kidney dysfunction (EGFR ≤ 20 mlgmin/1.73 m2, conventional dialysis or patients who have started dialysis; Child Pugh grade C/cirrhosis)
8. History of open heart surgery;
9. Hemodynamic instability or severe heart failure (SBP\<90 mmHg or preoperative need of high-dose vasoactive drug support, placement of aortic balloon pump (IABP), ECMO or ventricular assist device, left ventricular ejection fraction\<30%)
10. Adverse drug reactions to trial medications
11. History of malignant hyperthermia
12. Pregnancy or lactation

Where it's running

• Xijing Hospital
  Xi'an, Shaanxi, China Recruiting
• Tianjin Chest Hospital
  Tianjin, Tianjin Municipality, China Recruiting
• Changhai Hospital
  Shanghai, China Recruiting
• Fuzhou University Affiliated Provincial Hospital
  Fuzhou, Fujian, China Not yet recruiting
• Cangzhou People's Hospital
  Cangzhou, Hebei, China Not yet recruiting
• Hebei General Hospital
  Shijiazhuang, Hebei, China Not yet recruiting

Study contacts

• Principal investigator: Chong Lei, M.D., phd — Xijing Hospital
• Study coordinator: Chong Lei, M.D.& phd
• Email: crystalleichong@126.com
• Phone: 18629011362

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.