Using propolis to relieve menstrual pain in women with endometriosis receiving a levonorgestrel implant
Effect of Propolis Administration as Levonorgestrel (LNG) Implant Adjuvant for Dysmenorrhea in Endometriosis: Focus on Clinical Improvement, Oxidative Stress Biomarkers and Inflammation
This study is testing if taking propolis can help women with endometriosis who are using a levonorgestrel implant feel less menstrual pain.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 20 Years to 49 Years |
| Sex | Female |
| Sponsor | Indonesia University Academic / other |
| Locations | 1 site (Jakarta, Jakarta Pusat) |
| Trial ID | NCT05770297 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of propolis administration on dysmenorrhea in women with endometriosis who are receiving a levonorgestrel implant. Participants will receive either propolis or a placebo twice daily, and the study aims to determine if propolis can reduce menstrual pain and oxidative stress biomarkers associated with endometriosis. The trial will compare the outcomes between the treatment and control groups to assess the efficacy of propolis in alleviating symptoms.
Who should consider this trial
Good fit: Ideal candidates are women aged 20-49 with endometriosis who experience menstrual pain and are willing to receive a levonorgestrel implant.
Not a fit: Patients with liver impairment, certain chronic diseases, or those who have previously consumed propolis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a natural treatment option for reducing menstrual pain in women with endometriosis.
How similar studies have performed: While the use of propolis in this context is novel, other studies have explored its anti-inflammatory properties, suggesting potential benefits.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 20-49 years and already menstruating with complaints of menstrual pain referred to the obstetrics and gynecology polyclinic for LNG implant placement * Willing to have LNG implant installed after receiving explanation about implants * Not receiving hormonal treatment for endometriosis within the last 3 months * Can receive drops (propolis) during the study Exclusion Criteria: * Impaired liver function, degenerative diseases (DM, hypertension and cardiovascular disease), benign tumors, cancer * Pregnancy and breastfeeding * Hypersensitivity to levonogestrel * Thromboembolic disease * Experiencing bleeding for unknown reasons * History of allergies to honey and its processed products * Currently taking supplements/drugs that are not included in the standard management of endometriosis patients at RSCM * Have consumed propolis before * Received hormonal treatment within the last 3 months
Where this trial is running
Jakarta, Jakarta Pusat
- Cipto Mangunkusumo Hospital — Jakarta, Jakarta Pusat, Indonesia (Recruiting)
Study contacts
- Principal investigator: Dwirini Retno Gunarti, Dr drg Master of Science
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.