Using PRF to enhance healing before radiation therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of Platelet Rich Fibrin (PRF) on wound healing in patients undergoing tooth extractions prior to radiation therapy for head and neck cancer. Patients will receive either PRF treatment or natural healing in their extraction sockets, with the aim of preventing complications such as osteoradionecrosis. The study will also monitor pain perception during the healing process. Participants must have bilateral tooth extractions and will be randomly assigned to receive PRF in one socket while the other socket heals naturally.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Head and neck cancer with planed radiation therapy
* Bilateral tooth extraction
* Similar tooth size
* Atraumatic tooth extractions without flap surgery
* Patients age above 18y of age

Exclusion Criteria:

* Prior radiation therapy in the head and neck area
* Prior and current therapy with bisphosphonates or equivalent modern biologics
* Patients during pregnancy or breastfeeding

Where it's running

• University of Giessen
  Giessen, Hesse, Germany Recruiting

Study contacts

• Study coordinator: Sameh Attia, DDS, MSc
• Email: Sameh.Attia@dentist.med.uni-giessen.de
• Phone: ‭(+49) 641 9946112‬

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.