Using multimodal anesthesia for elderly patients undergoing lumbar spine surgery
Effects of Multimodal General Anesthesia for Older Patients Undergoing Lumbar Spine Fusion Surgery: a Randomized Controlled Trial
This study is testing a new way of using anesthesia during back surgery to see if it helps older patients recover better and have fewer complications like confusion after the surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 160 (estimated) |
| Ages | 60 Years to 90 Years |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Trial ID | NCT05247177 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of multimodal general anesthesia on the recovery of elderly patients undergoing lumbar spine fusion surgery. It utilizes a combination of sevoflurane, ketamine, and dexmedetomidine, guided by electroencephalography density spectrum array, to enhance anesthetic effects while minimizing dosages. The goal is to improve postoperative recovery and reduce complications such as delirium and cognitive impairment, which are common in this patient population. By comparing this approach to conventional anesthesia, the study aims to identify potential benefits in recovery profiles.
Who should consider this trial
Good fit: Ideal candidates are elderly patients aged 60 and above who are scheduled for elective lumbar spine surgery.
Not a fit: Patients with a history of dementia, impaired liver or renal function, or significant cardiac dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance recovery outcomes and reduce postoperative complications for elderly patients undergoing lumbar spine surgery.
How similar studies have performed: Other studies have shown promising results with multimodal anesthesia approaches, suggesting potential for success in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. patients with ages at least 60-year undergoing elective lumbar spine surgery Exclusion: 1. A history of dementia 2. Impaired liver function, eg. AST or ALT \>100; liver cirrhosis \> Child B class 3. Impaired renal function, cGFR\< 60 ml/min/1.73 m2 4. Cardiac dysfunction, such as heart failure \> NYHA class II
Where this trial is running
Taipei
- National Taiwan University Hospital — Taipei, Taiwan (Recruiting)
Study contacts
- Principal investigator: Chun-Yu Wu, MD — National Taiwan University Hospital
- Study coordinator: Chun-Yu Wu
- Email: longersolo@gmail.com
- Phone: 0972653376
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.