Using iTBS to treat acute ischemic stroke after thrombectomy
Official title: Efficacy and Safety of Intermittent Theta Burst Stimulation in Acute Anterior Circulation Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
Run by The First Hospital of Jilin University · NCT06941961 · Data updated 2026-11-12
This study is testing if a new brain stimulation treatment can help adults recover better after having a stroke and getting a blood clot removed.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 178 (estimated) |
| Sponsor | The First Hospital of Jilin University Academic / other |
| Locations | 1 site (Changchun, Jilin) |
| Status | Recruiting |
| Started | April 25, 2025 |
| Main results expected | July 1, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | April 30, 2025 |
| Trial ID | NCT06941961 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-85 who have had an acute ischemic stroke due to large vessel occlusion and have undergone successful mechanical thrombectomy.
✕Probably not a fit
Patients with severe pre-existing disabilities, significant cognitive dysfunction, or contraindications to iTBS may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness and safety of intermittent theta burst stimulation (iTBS) as an additional therapy for patients who have experienced an acute ischemic stroke and have undergone successful mechanical thrombectomy. The study involves a randomized, single-blind, parallel-controlled design, focusing on adults aged 18-85 with specific NIHSS scores after their procedure. Participants will receive either active iTBS or a sham treatment to assess the potential benefits of this innovative approach in stroke recovery.
Why it matters
Potential benefit: If successful, this treatment could enhance recovery outcomes for patients suffering from acute ischemic stroke.
How similar studies have gone: While the use of iTBS is a novel approach in this context, similar studies in other neurological conditions have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\) Age 18-85 years, regardless of gender. * 2\) Acute ischemic stroke caused by occlusion of the anterior circulation large vessels (internal carotid artery, M1 or M2 segment of the middle cerebral artery), verified by CTA or DSA. * 3\) Mechanical thrombectomy (MT) performed within 24 hours of symptom onset. * 4\) Successful Reperfusion: Post-MT eTICI score ≥ 2b. * 5\) NIHSS score 5-25 at 24 hours post-MT, with ≥2 points in at least one limb. Exclusion Criteria: * 1\) Pre-stroke modified Rankin Scale (mRS) score ≥2. * 2\) PH2-type intracranial hemorrhage on brain CT post-MT. * 3\) Patients who underwent intracranial stent placement during MT. * 4\) Contraindications to iTBS: History of epilepsy or seizures, implanted cardiac pacemakers, cochlear implants, or other electronic/magnetic-sensitive devices. * 5\) Severe consciousness impairment, cognitive dysfunction, or psychiatric disorders preventing compliance with iTBS. * 6\) Expected survival \<3 months due to other medical conditions or inability to complete follow-up for any reason. * 7\) Participation in another interventional study. * 8\) Any other condition deemed unsuitable for enrollment by the investigator.
Where it's running
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The First Hospital of Jilin University
Changchun, Jilin, China Recruiting
Study contacts
- Study coordinator: Yi Yang, MD, PhD
- Email: doctor_yangyi@163.com
- Phone: 0086-13756661217
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.