Using INTELLiVENT for ventilation after cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial compares the effectiveness of INTELLiVENT-adaptive support ventilation (ASV) against conventional ventilation methods in patients recovering from cardiac surgery. It aims to assess the quality of ventilation and the workload on ICU nursing staff, while also evaluating clinical outcomes such as the duration of postoperative ventilation and length of ICU stay. The study involves an international cohort of participants and is designed to provide insights into the benefits of adaptive ventilation techniques in a critical care setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. aged \> 18 years of age;
* 2\. scheduled for elective cardiac surgery; and
* 3\. expected to receive postoperative ventilation in the ICU for \> 2 hours.

Exclusion Criteria:

1. any emergency or semi-elective surgery (precluding informed written consent);
2. any surgery other than CABG, valve replacement or repair, or a combination (i.e., patients planned for surgery for congenital heart disease, or scheduled for heart transplantation are excluded);
3. enrolled in another interventional trail;
4. no written informed consent obtained;
5. history of recent pneumectomy or lobectomy;
6. history of COPD with oxygen at home;
7. body mass index \> 35;
8. preoperative forced expiratory volume in the first second (FeV1)/forced vital capacity (VC) \< 50% (if available);
9. preoperative arterial oxygen partial pressure (PaO2) \< 60 mm Hg (at room air);
10. preoperative arterial carbon dioxide partial pressure (PaCO2) \> 50 mm Hg;
11. preoperative left ventricular ejection fraction \< 30% (if available);
12. preoperative systolic pulmonary artery pressure \> 60 mm Hg (if available);
13. preoperative left ventricular mechanical support, e.g., Impella®; or
14. preoperative use of veno-venous or veno-arterial extracorporeal support

    At the end of surgery, patients are additionally excluded if a patient:
15. cannot be weaned from the extracorporeal support; or
16. unexpectedly needs implementation of an assist device

Where it's running

• Medical University of Vienna
  Vienna, State of Vienna, Austria Recruiting

Study contacts

• Principal investigator: Edda Tschernko, MD — Medical University of Vienna
• Study coordinator: Edda Tschernko, MD
• Email: edda.tschernko@meduniwien.ac.at
• Phone: 00 43 1 40400 41090

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.