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Clinical trial Recruiting at 1 site Interventional Ages 1 Hour to 24 Hours

Evaluating non-invasive ventilation methods for preterm infants with respiratory distress

Official title: Evaluation of Nasal Non Invasive Ventilation Modalities in Management of Neonates With Respiratory Distress Using Lung Ultrasound

Run by Alexandria University · NCT06550219 · Data updated 2026-11-12

This study is testing different breathing support methods for premature babies with breathing problems to see which one helps them the best.

Quick facts

Study typeInterventional
Ages1 Hour to 24 Hours
SexAll
Enrollment30 (estimated)
SponsorAlexandria University
Academic / other
Locations1 site (Alexandria)
StatusRecruiting
StartedNovember 20, 2024
Main results expectedMay 28, 2025
Study endsNovember 1, 2025
Registry record updatedFebruary 4, 2025
Trial IDNCT06550219 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are preterm infants under 37 weeks gestational age who are admitted to the NICU with signs of respiratory distress.

Probably not a fit

Patients with major congenital abnormalities or those requiring invasive mechanical ventilation will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of various non-invasive ventilation methods, including nasal intermittent positive pressure ventilation (nIPPV), nasal continuous positive airway pressure (nCPAP), and nasal high flow cannula (NHFC), in managing respiratory distress in preterm neonates under 37 weeks gestational age. The primary focus is on the duration of non-invasive ventilation, while secondary outcomes include the need for intubation, duration of respiratory support, and assessment of lung function using lung ultrasound. The study aims to provide insights into the best practices for respiratory support in vulnerable newborns.

Why it matters

Potential benefit: If successful, this study could improve respiratory management strategies for preterm infants, potentially reducing the need for invasive interventions.

How similar studies have gone: Similar studies have shown promise in using non-invasive ventilation techniques for preterm infants, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria: Preterm \<37 wk. gestational age admitted to the NICU with spontaneous breathing and clinical manifestations of RD (tachypnea, nasal flaring, intercostal and subcostal retraction and or grunting).

Exclusion Criteria:

1. Obvious major congenital abnormalities.
2. Any of the baby intubated for resuscitation or for other reasons.
3. Neonates need invasive mechanical ventilation.
4. Pulmonary hemorrhage.
5. Severe cardiovascular instability.
6. Cardiopulmonary arrest needing prolonged resuscitation.
7. Birth asphyxia (one-minute Apgar score ≤ 3).
8. Major cardiac diseases (not including patent ductus arteriosus).

Where it's running

  • Alexandria university, Elshattbi hospital
    Alexandria, Egypt     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.