Home › Trials › NCT07004192
Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 and up Women only

Using hCG to trigger a corpus luteum before a thawed embryo transfer

Official title: The Role of hCG in Thawed Embryo Transfer

Run by Fertility Center of Las Vegas · NCT07004192 · Data updated 2026-11-12

This trial will test whether giving a single hCG injection to create a corpus luteum helps people have better success with a thawed embryo transfer.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexWomen only
Enrollment220 (estimated)
SponsorFertility Center of Las Vegas
Industry-sponsored
Locations1 site (Las Vegas, Nevada)
StatusRecruiting
StartedJune 2, 2025
Main results expectedDecember 31, 2027
Study endsDecember 31, 2027
Registry record updatedJuly 1, 2025
Trial IDNCT07004192 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adult, non‑menopausal women planning transfer of at least one thawed blastocyst of transferable quality who can provide informed consent in English and attend the Fertility Center of Las Vegas are ideal candidates.

Probably not a fit

Patients under 18, those using embryos frozen at another center, those requiring anticoagulation in pregnancy (for example due to antiphospholipid syndrome), patients insisting on a two-embryo transfer, or those unable to consent in English are not eligible and therefore unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective randomized trial that assigns adults undergoing thawed blastocyst transfer to one of two arms that differ only by whether they receive an hCG injection to induce a corpus luteum. All other medications and transfer procedures are kept identical between groups to isolate the effect of the corpus luteum. Pregnancy and implantation outcomes after the transfer will be followed to compare the two approaches. The protocol allows use of PGT, donor gametes, and gestational carriers while excluding patients with indications for anticoagulation or embryos frozen at another center.

Why it matters

Potential benefit: If successful, this could show whether inducing a corpus luteum with hCG increases pregnancy or live birth rates after thawed embryo transfer, helping clinicians optimize luteal support.

How similar studies have gone: Some prior observational and randomized work suggests the presence of a corpus luteum can affect outcomes after frozen embryo transfer, but randomized trials that use hCG as the sole differing intervention are limited and have shown mixed results.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Female adult expecting to receive transfer of a thawed embryo.
2. At least one available frozen blastocyst of transferrable quality.
3. Non-menopausal female with at least one antral follicle.
4. Use of pre-implantation genetic testing (PGT), embryos derived from donor oocytes and/or donor sperm, a gestational carrier, and history of prior transfer(s) regardless of outcome are allowed.
5. Subsequent embryo transfers after failed transfers under this study are allowed, but not after a transfer that has resulted in ongoing pregnancy at ten weeks gestation under this study.

Exclusion Criteria:

1. Minors (age\<18 years).
2. Use of embryo(s) frozen at another center.
3. Patient insistent on transfer of two embryos.
4. Patient or partner unable to provide informed consent in English.
5. Patient already enrolled in any other research study for her embryo transfer.
6. History of anti-phospholipid syndrome or any other indication for use of Lovenox in pregnancy.
7. Patient for whom the physician assesses this protocol is inappropriate or unsafe.

Where it's running

  • Fertility Center of Las Vegas
    Las Vegas, Nevada, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Infertility (IVF Patients) 23
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.