Using genetic testing to improve emergency care
Official title: Trial of Precision Medicine in Emergency Departments
Run by University of Florida · NCT06448091 · Data updated 2026-11-12
This study is testing if using genetic testing in emergency rooms can help doctors choose better treatments and reduce the number of times patients need to come back.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 1200 (estimated) |
| Sponsor | University of Florida Academic / other |
| Locations | 3 sites (Gainesville, Florida and 2 other locations) |
| Status | Recruiting |
| Started | March 18, 2025 |
| Main results expected | February 1, 2029 |
| Study ends | February 1, 2029 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT06448091 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 40 and older who have had multiple prior emergency department visits and are receiving a new prescription for a pharmacogenetic medication.
✕Probably not a fit
Patients with prior pharmacogenetic test results or severe liver or renal conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the feasibility of implementing preemptive pharmacogenetic testing in emergency departments to improve patient outcomes. It will assess whether this testing, combined with decision support, can reduce return visits to the emergency department and hospitalizations. The trial will be conducted in several UF Health emergency departments and will involve a randomized, controlled approach to measure both effectiveness and implementation outcomes.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized medication management in emergency settings, potentially reducing complications and hospital readmissions.
How similar studies have gone: Other studies have shown promise in using pharmacogenetic testing to improve medication management, indicating that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults 40 years or older presenting to a participating ED 2. Receipt of a new order/prescription for a selected PGx medication (Appendix 1), with a duration greater than 7 days, during the current ED visit or within 30 days prior. 3. Documentation of at least 2 prior ED or urgent care visits within the past 12 months Exclusion Criteria: 1. Prior clinical pharmacogenetic test results within the EHR for genes relevant for this study (Appendix 1). 2. History of hepatic or renal transplant 3. History of severe liver disease (stage Child-Pugh C) or renal disease eGFR \<15 ml/min. 4. Any medical condition that would prohibit the ability to complete the study 5. Prisoners, wards of the state, or patients being held under the Baker Act or Marchman Act 6. Life expectancy less than 6 months
Where it's running
-
UF Health Jacksonville Downtown Emergency Department
Jacksonville, Florida, United States Recruiting -
UF Health Jacksonville North Emergency Department
Jacksonville, Florida, United States Recruiting -
UF Health Emergency Department
Gainesville, Florida, United States Not yet recruiting
Study contacts
- Principal investigator: Julio D Duarte, Pharm.D., Ph.D. — University of Florida
- Study coordinator: Erica N Elwood, MHA
- Email: erica.elwood@cop.ufl.edu
- Phone: 3522736007
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.