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Clinical trial No longer in our active list Observational Ages 18 Minutes and up

Using ENB-guided ablation therapy with VATS for multiple lung cancers

Official title: Electromagnetic Navigation Bronchoscopy Guided Ablation Therapy Combined With VATS in the Treatment of Multiple Primary Lung Cancers

Run by Shanghai Chest Hospital · NCT04730453 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if a new treatment that combines a special lung procedure with surgery can help people with multiple lung cancers feel better and live longer.

Quick facts

Study typeObservational
Ages18 Minutes and up
SexAll
Enrollment30 (estimated)
SponsorShanghai Chest Hospital
Academic / other
Locations1 site (Shanghai, Shanghai)
Trial IDNCT04730453 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older diagnosed with multiple primary lung cancer who meet specific imaging and treatment criteria.

Probably not a fit

Patients who cannot tolerate general anesthesia or have other significant health contraindications may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness and safety of combining electromagnetic navigation bronchoscopy (ENB)-guided ablation therapy with video-assisted thoracic surgery (VATS) for patients diagnosed with multiple primary lung cancers (MPLC). Patients will be screened for eligibility based on specific criteria, and those who qualify will receive the combined treatment. The primary goal is to assess the objective response rate, while secondary goals include measuring progression-free survival, overall survival, and safety outcomes.

Why it matters

Potential benefit: If successful, this approach could improve treatment outcomes for patients with multiple primary lung cancers.

How similar studies have gone: While this approach is innovative, similar studies have shown promise in using combined techniques for lung cancer treatment.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age ≥ 18 years old.
2. The subject is diagnosed as multiple primary lung cancer via preoperative imaging/pathological examination.
3. Thin-slice CT images show that the ablation Lesion A is accessible/adjacent to bronchi and the size is ≤ 3 cm.
4. The subject with multiple primary lung cancers can be treated with ENB-guided ablation therapy combined with VATS according to multidisciplinary assessment.

Exclusion Criteria:

1. The subject who cannot tolerate general anesthesia for their cardiopulmonary function, or there are other contraindications, such as uncorrectable coagulopathy.
2. The situation in which the investigators think that the subject is not suitable to participate in this study.

Where it's running

  • Shanghai Chest Hospital
    Shanghai, Shanghai, China     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.