Olive oil before lung cancer surgery to see if it lowers chylothorax
Official title: A Multicenter, Prospective, Randomized Controlled Trial of Preoperative Oral Olive Oil for the Prevention of Postoperative Chylothorax in Patients With Lung Cancer
Run by Fudan University · NCT07807696 · Data updated 2026-11-12
This study tests whether drinking 40 mL of extra-virgin olive oil a few hours before lung cancer surgery can reduce chylothorax after tumor removal.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 1036 (estimated) |
| Sponsor | Fudan University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Shanghai, Xuhui) |
| Status | Recruiting |
| Started | March 15, 2026 |
| Main results expected | June 1, 2027 |
| Study ends | December 30, 2030 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT07807696 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 18–80 with resectable lung cancer, ECOG 0–1, no prior lung cancer surgery, no prior radiotherapy/chemotherapy, and able to take food orally.
✕Probably not a fit
Patients who cannot tolerate preoperative olive oil, have olive oil allergies, or have conditions that affect fat digestion may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this multicenter randomized trial, adults with resectable lung cancer will be assigned to preoperative olive oil or standard fasting, to see if olive oil reduces chylothorax within 30 days post-surgery. The primary outcome is chylothorax occurrence; secondary outcomes include need for repeat surgery, other postoperative complications, chest drainage metrics, length of chest tube and hospital stay, and safety of the intervention. The study aims to enroll 1,036 participants in a 1:1 ratio across intervention and control groups. Participants must be adults 18–80 with good performance status and no prior lung cancer surgery or radiotherapy.
Why it matters
Potential benefit: If successful, preoperative olive oil could lower chylothorax risk and improve recovery after lung cancer surgery.
How similar studies have gone: Previous research on preoperative dietary strategies for surgical risk reduction is limited; this trial applies a novel preoperative olive oil approach to a specific postoperative complication.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Voluntary participation and willing and able to complete all study procedures. * Age 18 to 80 years, inclusive, at informed consent. * Eastern Cooperative Oncology Group performance status of 0 or 1. * Resectable lung cancer. * No prior surgery for lung cancer. * Treatment-naive and no prior radiotherapy or chemotherapy. * Able to take food orally before surgery. Exclusion Criteria: * Allergy to olive oil or any of its components. * History of acute or chronic pancreatitis or severe biliary disease. * Fat malabsorption syndrome. * Prior ipsilateral thoracic surgery or thoracic radiotherapy or chemotherapy. * Unable to comply with preoperative dietary instructions.
Where it's running
-
Fudan University Shanghai Cancer Center
Shanghai, Xuhui, China Recruiting
Study contacts
- Study coordinator: Hang Cao, MD
- Email: 16301050173@fudan.edu.cn
- Phone: +86 18717722753
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.