Using diuretic renogram to identify significant obstruction in ureteropelvic junction syndrome
Official title: Cortical Transit Time on Diuretic Renogram as an Early Marker of Significant Obstruction in Antenatally Detected Uretero-pelvic Junction Syndrome
Run by Centre Hospitalier Universitaire de la Réunion · NCT02812212 · Data updated 2026-11-12
This study is testing if a special kidney scan can help doctors tell if infants with ureteropelvic junction obstruction need surgery to prevent kidney damage.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 4 Weeks to 8 Weeks |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de la Réunion Academic / other |
| Locations | 5 sites (Bordeaux and 4 other locations) |
| Status | Recruiting |
| Started | November 28, 2017 |
| Main results expected | November 2026 |
| Study ends | April 2027 |
| Registry record updated | September 29, 2022 |
| Trial ID | NCT02812212 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are infants aged 4 to 8 weeks with antenatally detected unilateral ureteropelvic junction obstruction.
✕Probably not a fit
Patients with bilateral UPJO, associated contralateral uropathy, or severe disabilities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the use of cortical transit time on diuretic renograms as an early marker for significant obstruction in infants diagnosed with ureteropelvic junction obstruction (UPJO) detected antenatally. It aims to differentiate between reversible antenatal hydronephrosis and pathological UPJO, which can lead to renal damage if untreated. The study involves infants aged 4 to 8 weeks who have been diagnosed with UPJO and will undergo ultrasonography and diuretic renography to assess their condition. The goal is to improve the management of UPJO by providing reliable prognostic criteria for surgical intervention.
Why it matters
Potential benefit: If successful, this study could lead to earlier and more accurate identification of significant UPJO, potentially preventing renal damage in affected infants.
How similar studies have gone: While the use of diuretic renography is common, this specific approach to early identification of significant obstruction in UPJO is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Infants: * Aged of 4 to 8 weeks of life * Presenting an ureteropelvic junction obstruction (UPJO) detected before birth by ultrasound * Presenting an UPJO, defined by an Antero-Posterior Renal Pelvic Diameter greater or equal to 15 mm, confirmed by ultrasound post-natally between the 1st and 15th day of life * Presenting a unilateral UPJO * whose legal representatives have provided a signed free and informed written consent for their infant's participation * whose at least one of his legal representative is affiliated to national social security Exclusion Criteria: Infants presenting: * A bilateral UPJO * An ureteral dilatation * An associated contralateral uropathy * A solitary kidney * A renal insufficiency * Severe associated disabilities ( ie polymalformation syndromes) * A concomitant participation in another trial * A contraindication to furosemide (acute renal insufficiency, hepatic encephalopathy, hypovolemia or dehydration, severe hypokalemia, severe hyponatremia) * A contraindication to the radionuclide marker (hypersensitivity to the active substance or to excipients)
Where it's running
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CHU de Bordeaux
Bordeaux, France Recruiting -
CHU de Limoges
Limoges, France Recruiting -
Centre Hospitalier Universitaire de La Réunion
Saint-Denis, France Recruiting -
CHU de Nantes
Nantes, France Not yet recruiting -
CHU de Rennes
Rennes, France Not yet recruiting
Study contacts
- Principal investigator: Luke Harper, MD — University Hospital, Bordeaux
- Study coordinator: Lucie Auzanneau
- Email: lucie.auzanneau@chu-reunion.fr
- Phone: 0262359949
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Can Renal Shear Wave Elastography predict kidney recovery after pyeloplasty in kids with UPJO
This study tests whether kidney stiffness measured by renal cortical shear wave elastography before and after surgery can predict how much kidney function will recover in children with unilateral UPJO after open pyeloplasty.
-
Using ultrasound to visualize kidney issues in children with congenital anomalies
This study is testing if special ultrasound techniques can help doctors see kidney problems in children with birth defects affecting their kidneys and urinary tract.
-
Investigating biomarkers for kidney obstruction in young children
This study is trying to find specific markers in urine and blood that can help doctors better diagnose kidney blockages in young children who need surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.