Investigating biomarkers for kidney obstruction in young children
Official title: PRecocious biOmarkers oF Unilateral ureTero-pelvic jUnction obstRuction in childrEn
Run by University of Campania Luigi Vanvitelli · NCT06382233 · Data updated 2026-11-12
This study is trying to find specific markers in urine and blood that can help doctors better diagnose kidney blockages in young children who need surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Day to 5 Years |
| Sex | All |
| Enrollment | 85 (estimated) |
| Sponsor | University of Campania Luigi Vanvitelli Academic / other |
| Locations | 5 sites (Naples, Campania and 4 other locations) |
| Status | Recruiting |
| Started | January 30, 2024 |
| Main results expected | January 30, 2026 |
| Study ends | January 30, 2028 |
| Registry record updated | April 30, 2024 |
| Trial ID | NCT06382233 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 0-5 years diagnosed with unilateral ureteropelvic junction obstruction.
✕Probably not a fit
Patients with bilateral UPJO or those who have had previous surgical interventions on the urinary tract may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify specific biomarkers associated with unilateral ureteropelvic junction obstruction (UPJO) in children who require surgical intervention. It compares these biomarkers in affected children to controls, focusing on urinary single-cell and extracellular vesicles to assess kidney injury and repair processes. The study also explores whole blood gene expression profiling to improve the accuracy of UPJO diagnosis. By utilizing biofluids for diagnosis, the study seeks to enhance risk stratification and reduce reliance on traditional imaging techniques.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and better management of kidney obstruction in children, potentially preventing progressive kidney damage.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in utilizing biomarkers for kidney conditions, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * unilateral UPJO * 0-5years of age Exclusion Criteria: * bilateral UPJO * previous surgical intervention on the urinary tract * bladder or lower urinary tract symptoms or malformations * nephro- or urolithiasis, vesicoureteral reflux * urinary tract infections.
Where it's running
-
Univeristà degli Studi della Campania Luigi Vanvitelli
Naples, Campania, Italy Recruiting -
Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico
Milan, Italy Recruiting -
Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia
Modena, Italy Recruiting -
AORN Santobono-Pausilipon
Naples, Italy Recruiting -
Department of Clinical Sciences and Community Health, University of Milano
Milan, Italy Active not recruiting
Study contacts
- Study coordinator: Pierluigi Marzuillo, MD PhD
- Email: pierluigi.marzuillo@unicampania.it
- Phone: 00390815665344
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.