Can Renal Shear Wave Elastography predict kidney recovery after pyeloplasty in kids with UPJO

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational cohort study enrolls children aged 6 months to 18 years with unilateral UPJO scheduled for open dismembered pyeloplasty at Beni-Suef University. The research uses renal cortical shear wave elastography to measure kidney stiffness preoperatively and at follow-up, comparing changes to isotope-based renal function outcomes at 6 months. The primary goal is to see if the 3-month change in elastography predicts 6-month isotope-defined renal function recovery. Standard clinical imaging and diuretic renography are performed, with additional renal cortical scintigraphy as indicated. The study is designed to evaluate the potential of elastography as a noninvasive predictor of postoperative renal recovery in pediatric UPJO.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged 6 months to 18 years.
* Diagnosis of unilateral primary ureteropelvic junction obstruction.
* Planned for open dismembered pyeloplasty.
* Availability of preoperative renal ultrasonography, renal cortical shear wave elastography, and diuretic renography.
* Written informed consent obtained from parent or legal guardian.

Exclusion Criteria:

* Bilateral ureteropelvic junction obstruction.
* Secondary ureteropelvic junction obstruction.
* Previous ipsilateral upper urinary tract surgery.
* Associated major urinary tract anomalies likely to independently affect renal function, including vesicoureteral reflux, megaureter, duplex system, posterior urethral valves, or ectopic kidney.
* Active urinary tract infection at the time of assessment.
* Known intrinsic renal parenchymal disease unrelated to obstruction.
* Inability to obtain reliable shear wave elastography measurements.
* Incomplete planned follow-up.

Where it's running

• Department of Urology- Beni-Suef University Hospitals
  Banī Suwayf, Beni Suweif Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Hany F Badawy — Faculty of medicine, BeniSuef University
• Study coordinator: Hany F Badawy, MD
• Email: HANYFATHY86@GMAIL.COM
• Phone: +201149525028

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.