Using dexmedetomidine with bupivacaine for pain relief after knee surgery
Impact of Dexmedetomidine Add to Intra-articular Bupivacaine for Post Operative Analgesia After Knee Arthroscopic Surgery
This study is testing if adding dexmedetomidine to bupivacaine can help people feel less pain after knee surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 2 sites (Asyut and 1 other locations) |
| Trial ID | NCT06665438 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of adding dexmedetomidine to bupivacaine for postoperative pain management in patients undergoing knee arthroscopy for anterior cruciate ligament reconstruction. It is a prospective double-blind trial involving 75 patients at Al Azhar University Hospital in Assiut, Egypt. Participants will receive either the combination of dexmedetomidine and bupivacaine or bupivacaine alone to compare their analgesic effects after surgery.
Who should consider this trial
Good fit: Ideal candidates are ASA I-II patients aged 18-65 who are scheduled for ACL reconstruction via knee arthroscopy.
Not a fit: Patients with kidney or liver failure, heart disease, diabetes, or a history of drug allergies to the study medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain management for patients recovering from knee arthroscopy.
How similar studies have performed: Previous studies have shown promising results with similar analgesic combinations, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-II patients * Either sex * Aged 18-65 years * Candidates for anterior cruciate ligament (ACL) reconstruction by knee arthroscopy * Exclusion Criteria: * the patients with kidney failure, liver failure, valvular and ischemic heart disease , high blood pressure, diabetes, history of infection and malignancy. * history of coagulation diseases, and history of drug allergies to used drugs. * those who consumed NSAIDs and analgesics 24 h before surgery were excluded from the study.
Where this trial is running
Asyut and 1 other locations
- Al-Azhar University — Asyut, Egypt (Recruiting)
- Al-Azhar University — Asyut, Egypt (Not_yet_recruiting)
Study contacts
- Study coordinator: Mohamed A. Mahmoud, MD
- Email: mohamedali.226@azhar.edu.eg
- Phone: 01002538320
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.