Using coronary CT angiography before catheter ablation in patients with atrial fibrillation
Coronary Computed Tomography AngioGraphy Prior to Catheter Ablation in Patients With Atrial FIBrillation
This study is testing if getting a special heart scan before a procedure for atrial fibrillation can help patients feel better and reduce the chances of their heart issues coming back.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 852 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Herlev and Gentofte Hospital Academic / other |
| Locations | 1 site (Hellerup, Capital Region) |
| Trial ID | NCT05978388 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates whether performing coronary computed tomography (CT) angiography prior to catheter ablation can enhance clinical outcomes for patients with atrial fibrillation. Approximately 852 patients aged 18 and older will be randomized to either receive coronary CT angiography analysis or not during their catheter ablation procedure. The study aims to determine if the results from the CT angiography can lead to improved treatment strategies, including intensified medical treatment or referrals for further interventions. Participants will be monitored for at least one year post-ablation to assess the recurrence of atrial tachyarrhythmia.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old referred for catheter ablation treatment for atrial fibrillation.
Not a fit: Patients with known atherosclerotic cardiovascular disease or contraindications for coronary CT angiography may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to better management and outcomes for patients with atrial fibrillation undergoing catheter ablation.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in improving outcomes through advanced imaging techniques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years. * Referral for catheter ablation treatment (excluding AV-junction ablation) for atrial fibrillation (both paroxysmal and persistent atrial fibrillation) at the Department of Cardiology at Gentofte Hospital. Both first ablation and re-ablation treatments are included. * The ability and willingness to provide written informed consent. Exclusion Criteria: * Known atherosclerotic cardiovascular disease (ASCVD). * Ongoing treatment with statins. * Contraindications for coronary CT angiography, e.g. contrast allergy * Recent coronary CT angiography including CAC-score without positive findings \<3 years prior to screening. * Any surgical or medical condition, which in the opinion of the investigator, may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study.
Where this trial is running
Hellerup, Capital Region
- Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte — Hellerup, Capital Region, Denmark (Recruiting)
Study contacts
- Study coordinator: Caroline Espersen, MD
- Email: caroline.espersen@regionh.dk
- Phone: +4551180082
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.