Using coronary CT angiography before catheter ablation in patients with atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether performing coronary computed tomography (CT) angiography prior to catheter ablation can enhance clinical outcomes for patients with atrial fibrillation. Approximately 852 patients aged 18 and older will be randomized to either receive coronary CT angiography analysis or not during their catheter ablation procedure. The study aims to determine if the results from the CT angiography can lead to improved treatment strategies, including intensified medical treatment or referrals for further interventions. Participants will be monitored for at least one year post-ablation to assess the recurrence of atrial tachyarrhythmia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18 years.
* Referral for catheter ablation treatment (excluding AV-junction ablation) for atrial fibrillation (both paroxysmal and persistent atrial fibrillation) at the Department of Cardiology at Gentofte Hospital. Both first ablation and re-ablation treatments are included.
* The ability and willingness to provide written informed consent.

Exclusion Criteria:

* Known atherosclerotic cardiovascular disease (ASCVD).
* Ongoing treatment with statins.
* Contraindications for coronary CT angiography, e.g. contrast allergy
* Recent coronary CT angiography including CAC-score without positive findings \<3 years prior to screening.
* Any surgical or medical condition, which in the opinion of the investigator, may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study.

Where it's running

• Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte
  Hellerup, Capital Region, Denmark Recruiting

Study contacts

• Study coordinator: Caroline Espersen, MD
• Email: caroline.espersen@regionh.dk
• Phone: +4551180082

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.