Using brain feedback to reduce phantom limb pain in amputees

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a non-pharmacological operant conditioning approach to alleviate phantom limb pain (PLP) in individuals who have undergone limb amputation. Participants will receive non-painful peripheral stimulation while their brain responses are recorded using electroencephalography (EEG). They will receive real-time visual feedback to help promote normal sensorimotor responses over three sessions per week for 8-9 weeks, followed by follow-up assessments at 3 and 6 months. The study aims to evaluate the effectiveness of this method in reducing pain intensity and improving quality of life for those affected by PLP.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* An upper (or lower limb) amputation more than 6 months ago, that has produced a moderate to severe hand/arm (or foot/leg) phantom limb pain,
* Male or female age 18 years or older,
* Medical clearance to participate,
* Reasonable expectation that ongoing medications, if any, will be maintained without change for at least 4 months from the start of the study,
* Able to provide informed consent and to understand the study instructions,
* Able to participate in the specific study procedures.

Exclusion Criteria:

* Presence of other medically unstable and/or infectious condition (e.g., uncontrolled diabetes with recent weight loss, diabetic coma, frequent insulin reactions),
* A cardiac condition (e.g., history of myocardial infarction or congestive heart failure),
* Cognitive and/or attention difficulties affecting participant's ability to follow study directions,
* Known skin disorders or damaged skin at the anticipated at the scalp for EEG recording (e.g., unhealed wounds, broken skin).
* Metal implants above the chest

Where it's running

• Albany VA Medical Center Samuel S. Stratton, Albany, NY
  Albany, New York, United States Recruiting

Study contacts

• Principal investigator: Jodi A Brangaccio, PT — Albany VA Medical Center Samuel S. Stratton, Albany, NY
• Study coordinator: Jodi A Brangaccio, PT
• Email: Jodi.Brangaccio@va.gov
• Phone: (518) 626-5636

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.