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Clinical trial No longer in our active list Interventional Ages 18 to 80

Using augmented reality to locate lung nodules before surgery

Official title: Augmented Reality Assisted Lung Nodule Localization: a Multicentered, Prospective, Randomly Controlled, Non-inferiority Trial

Run by Shanghai Chest Hospital · NCT06548451 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if using augmented reality can help doctors find lung nodules more accurately before surgery, compared to the usual method, to improve outcomes for patients with lung cancer.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment270 (estimated)
SponsorShanghai Chest Hospital
Academic / other
Locations8 sites (Shanghai, Shanghai and 7 other locations)
Trial IDNCT06548451 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 to 80 with solitary pulmonary nodules that are less than 2 cm in diameter and require localization for sublobar resection.

Probably not a fit

Patients with multiple lung nodules or those whose nodules are located in the scapular region may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of augmented reality (AR) technology to assist in the localization of solitary pulmonary nodules prior to surgical procedures, specifically sublobar resections for lung cancer. The trial aims to compare the effectiveness of AR-guided localization against the traditional CT-guided hook-wire positioning method, which can be costly and traumatic for patients. By integrating AR into the surgical process, the study seeks to enhance the precision of nodule localization, potentially improving surgical outcomes and efficiency.

Why it matters

Potential benefit: If successful, this approach could lead to more accurate and less traumatic surgical procedures for patients with lung cancer.

How similar studies have gone: While the use of augmented reality in surgical settings is emerging, this specific application for lung nodule localization is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age between 18 and 80 years inclusive;
2. No distant metastasis in preoperative clinical assessment;
3. The attending physician's assessment confirms the need for lung nodule localization in patients undergoing sublobar resection;
4. Target lung nodule diameter is no more than 2 cm;
5. The inner edge of the target nodule is at least 2 cm away from the pulmonary artery or pulmonary vein;
6. Non-pleural surface nodules;
7. Preoperative ECOG performance status score of 0/1;
8. Voluntarily participating in this study and signing an informed consent form.

Exclusion Criteria:

1. More than two lung nodules need to be removed at the same time.
2. The target node is located in the scapular region. Because percutaneous localization is obstructed by the scapula, percutaneous localization of pulmonary nodules is not suitable for such patients.
3. Patients with chronic pain issues or those who have been taking pain medications for an extended period.
4. Patients have uncontrollable mental illness and cannot make subjective assessment.

Where it's running

  • Shanghai Chest Hospital
    Shanghai, Shanghai, China     Recruiting
  • Zhongshan Hospital
    Shanghai, Shanghai, China     Recruiting
  • the people's second hospital Hefei
    Hefei, China     Recruiting
  • Jiangyin Hospital of Traditional Chinese Medicine
    Jiangyin, China     Recruiting
  • Jining No. 1 People's Hospital.
    Jining, China     Recruiting
  • Donghai County People's Hospital
    Lianyungang, China     Recruiting
Show 2 more locations
  • the First Hospital of Hebei Medical University
    Shijia Zhuang, China     Recruiting
  • Zhangjiagang Hospital of Traditional Chinese Medicine,
    Zhangjiagang, China     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.