Using aerosolized lidocaine to manage intracranial pressure in severe brain injury patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of nebulized lidocaine compared to instilled lidocaine and normal saline before endotracheal suctioning in children with severe traumatic brain injury. It aims to determine if aerosolized lidocaine can reduce spikes in intracranial pressure during suctioning procedures. The study also assesses the feasibility and safety of using nebulized lidocaine in this patient population. Participants will be closely monitored for hemodynamic stability and intracranial pressure changes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients admitted to the PICU of Memorial Hermann Children's Hospital
* Severe TBI with a Glasgow Coma Scale score 4-8
* Intubated and mechanically ventilated with an ICP monitor in place.
* Continuous invasive monitoring of arterial pressure
* Hemodynamically Stable, defined by normal blood pressure for age before the ETS. We will not exclude patients with norepinephrine to maintain goal blood pressures to maintain Cerebral perfusion pressure(CPP).

Exclusion Criteria:

* Patients with sustained ICP \> 25 for more than 30 minutes mm Hg despite medical or neurosurgical intervention
* Moderate/Severe Acute respiratory distress syndrome (ARDS) with an oxygenation index \> 8
* Pulmonary hemorrhage
* Patients receiving neuromuscular blockade
* Use of other vasopressors for other causes of shock (cardiogenic, hypovolemic and septic)

Where it's running

• The University of Texas Health Science Center at Houston
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Thao L Nguyen, DO, FAAP — The University of Texas Health Science Center, Houston
• Study coordinator: Thao L Nguyen, DO, FAAP
• Email: Thao.L.Nguyen@uth.tmc.edu
• Phone: (713) 500-6287

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.