Using advanced ultrasound to predict outcomes of vascular access in kidney disease patients
Using Ultrasound 2D Strain Speckle Tracking, 2D Shear Wave Elastography and Transonic Flowmeter as Diagnostic and Potential Predictor Tool for Arteriovenous Fistula Outcomes With End Stage Renal Failure.
This study is testing whether advanced ultrasound measurements can help predict how well kidney disease patients will do after getting a special type of surgery to create a blood vessel for dialysis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Imperial College London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT04141358 on ClinicalTrials.gov |
What this trial studies
This observational pilot study focuses on patients with end-stage renal disease (ESRD) who are referred for arteriovenous fistula (AVF) procedures. The research team will collect clinical data and perform advanced ultrasound measurements to assess factors such as blood flow, vessel diameter, and arterial stiffness before, during, and after the AVF surgery. The study aims to evaluate the relationship between these ultrasound parameters and the success of the AVF, providing insights into potential predictors of AVF outcomes. Data will be gathered over a 21-month period, including pre-operative assessments and post-operative evaluations at six weeks.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 90 with end-stage renal disease and a glomerular filtration rate of less than 30 ml/min/1.73m2.
Not a fit: Patients who are under 18 years old, over 90 years old, or do not have end-stage renal disease will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the prediction of AVF outcomes, leading to better vascular access strategies for patients undergoing dialysis.
How similar studies have performed: While there have been studies on vascular access and ultrasound applications, this specific approach using advanced ultrasound techniques for predicting AVF outcomes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years age * \<90 years age * End stage renal disease * Glomerular filtration rate \< 30 ml/min/1.73m2 Exclusion Criteria: * \<18 years age * \> 90 years age * \< 2cm vein diameter * Not end-stage renal disease * Pregnant patients will not be recruited in this study. Patients pregnancy status will be assessed on initial enrolment to exclude them from the study. * Those unable to provide consent. * Anyone who is taking part in any other research. * Potential participants who might not adequately understand verbal explanations or written information given in English, or who have special communication needs will not be included
Where this trial is running
London
- Imperial College London — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Mohammed Aslam, PhD
- Email: m.aslam@imperial.ac.uk
- Phone: +44 20 3313 1541
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.