Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using a decision support system to prevent suicide attempts in emergency patients

Official title: Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors

Run by Massachusetts General Hospital · NCT05671133 · Data updated 2026-11-12

This study tests whether giving doctors special risk scores about patients' chances of attempting suicide can help prevent those attempts in people coming to the emergency room with mental health issues.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment4000 (estimated)
SponsorMassachusetts General Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedFebruary 25, 2025
Main results expectedMay 31, 2028
Study endsSeptember 28, 2028
Registry record updatedJune 22, 2026
Trial IDNCT05671133 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 years or older who present to an emergency psychiatry service.

Probably not a fit

Patients who are unable to understand study procedures or provide informed consent, such as those with severe cognitive impairments or acute intoxication, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to evaluate a comprehensive strategy for improving the prediction and prevention of suicide attempts among patients presenting to the emergency department with psychiatric concerns. The study will assess the effectiveness of providing clinicians with risk scores related to patient suicidal behavior. It hypothesizes that patients whose clinicians receive these risk scores will experience a lower rate of suicide attempts over a six-month follow-up period, facilitated by improved clinician decision-making. The study will involve a sample of 4,000 patients.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of suicide attempts among at-risk patients in emergency settings.

How similar studies have gone: Other studies have shown promise in using decision support systems to improve clinical outcomes, suggesting that this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult status (≥18 years-old);
* Willing to provide an email address;
* Presentation at the APS

Exclusion Criteria:

* Inability to understand the study procedures and provide informed consent such as those with gross cognitive impairment (including florid psychosis), intellectual disability, dementia, acute intoxication, or the presence of extremely agitated or violent behavior
* Decisions about inclusion/exclusion criteria will be made by the emergency department providers on duty at the time. These broad inclusion criteria maximize the clinical applicability of obtained results while the exclusion criteria ensure the ethical principle of respect for persons.

Where it's running

  • Massachusetts General Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • SAFETY family-based program for youths after a suicide attempt

    This project will test whether the SAFETY family-based therapy helps 10-17-year-olds who recently attempted suicide avoid repeat attempts.

    Recruiting at 4 sites Karolinska Institutet · Helsingborg and 4 other locations · NCT06931639

  • Intensive Crisis Intervention for teens with suicidal thoughts or behaviors

    This project will try a brief, family-focused Intensive Crisis Intervention to see if it helps 12–17-year-olds with suicidal thoughts or recent attempts reduce suicidal behavior and avoid inpatient psychiatric care.

    Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06476886

  • Preventing suicidal behavior in high-risk youth in emergency care settings

    This study is testing two different short interventions to see which one better helps young people aged 12-19 who are at risk of suicide when they come to the emergency room.

    Recruiting at 6 sites Johns Hopkins University · St. Petersburg, Florida and 5 other locations · NCT06151158

  • Enhanced Outreach After ED Visit to Prevent Suicide Attempts

    This study tests a weekly outreach program by a crisis organization after an ED visit for suicidal thoughts to see if it’s doable and helpful for participants.

    Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05825820

  • New treatment method for reducing suicidality after a crisis

    This study is testing a new short-term treatment for people who have recently tried to harm themselves to see if it can help reduce feelings of hopelessness and improve support from family and friends.

    Recruiting at 12 sites University Hospital, Ghent · Beernem and 11 other locations · NCT05638204

  • Identifying biomarkers for depression and suicide in adolescents

    This study is trying to find specific markers in the body that can help understand depression and suicidal thoughts in teenagers, while also looking at how standard treatments affect these issues.

    Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT05437588

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.