Preventing suicidal behavior in high-risk youth in emergency care settings
Official title: Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings
Run by Johns Hopkins University · NCT06151158 · Data updated 2026-11-12
This study is testing two different short interventions to see which one better helps young people aged 12-19 who are at risk of suicide when they come to the emergency room.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 12 Years to 24 Years |
| Sex | All |
| Enrollment | 484 (estimated) |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 6 sites (St. Petersburg, Florida and 5 other locations) |
| Status | Recruiting |
| Started | March 15, 2025 |
| Main results expected | June 15, 2028 |
| Study ends | July 15, 2029 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT06151158 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are youth aged 12-19 who present to emergency departments with suicide-related concerns or who screen positive for serious suicidal ideation.
✕Probably not a fit
Patients with significant cognitive or developmental delays that hinder their ability to understand or use the interventions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the effectiveness of two brief, evidence-based interventions aimed at preventing suicidal crises among youth aged 12-19 who present in emergency departments. The interventions include the Stanley Brown Safety Planning Intervention with Follow-up Contacts, which focuses on crisis de-escalation, and Interpersonal Psychotherapy for Adolescents Ultra Short Crisis Intervention, which addresses interpersonal issues contributing to suicidal thoughts. The research will take place in ethnically and racially diverse urban areas, including Philadelphia, Baltimore, and New York City, to ensure a broad representation of high-risk youth. The findings aim to inform future standards of care for suicidal adolescents in acute settings.
Why it matters
Potential benefit: If successful, this study could significantly reduce suicidal behavior among high-risk youth by identifying effective interventions for acute care settings.
How similar studies have gone: Other studies have shown promise in using similar interventions for suicide prevention, but this specific approach in acute care settings is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Suicide Risk During Acute Care Visit (At least one item must apply: Chief complaint of suicide-related concern, Active suicidal ideation endorsed in past 1 month on validated suicide screener, Suicidal behavior in the past 3 months on validated suicide screener, and/or Clinician indicated SI in past month or SA in past 3 months). * Have access to a cellular phone with the ability to receive phone calls and text messages over the 12-month follow- up period * Adolescent must be verbally fluent and can communicate, understand, and read in either English or Spanish * Adolescent has been/will be discharged from a higher level of care (i.e. inpatient, day hospital, partial hospitalization program (PHP), or residential treatment program) and back in the community within 4 weeks of the acute care visit. Exclusion Criteria: * Significant cognitive or developmental delays that prevent understanding or using SPI+ or IPT-A-SCI (includes inability to communicate verbally) * Altered mental status (acute psychosis, intoxication, or mania) * Unable or unwilling to provide informed consent (adults), assent (minors), or permission (parents/caregivers) * The services offered through the study are not in the best clinical interest of the patient (e.g., presenting problem requires a different level of care or treatment approach).
Where it's running
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Johns Hopkins All Children's Hospital
St. Petersburg, Florida, United States Recruiting -
Johns Hopkins University
Baltimore, Maryland, United States Recruiting -
Columbia University Irving Medical Center (CUMC)
New York, New York, United States Recruiting -
Weill-Cornell Medicine
New York, New York, United States Recruiting -
University of North Carolina Medical Center
Chapel Hill, North Carolina, United States Recruiting -
Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Holly C Wilcox, PhD — Johns Hopkins Bloomberg School of Public Health
- Study coordinator: Holly C Wilcox, PhD
- Email: hwilcox1@jhmi.edu
- Phone: 410-370-0081
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Caring Connections: youth suicide detection and support
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-
Multi-layered digital monitoring and pharmacogenomics to prevent suicide in adults with depression
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Combining the Youth-Nominated Support Team with CBT for Black adolescents at acute suicide risk
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This project will work with people in prison and prison care staff to test and adapt three suicide prevention tools so they fit prison life and are easier to use.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.