Clinical trial Recruiting at 6 sites Interventional Ages 12 to 24

Preventing suicidal behavior in high-risk youth in emergency care settings

Official title: Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings

Run by Johns Hopkins University · NCT06151158 · Data updated 2026-11-12

This study is testing two different short interventions to see which one better helps young people aged 12-19 who are at risk of suicide when they come to the emergency room.

Quick facts

Study typeInterventional
Ages12 Years to 24 Years
SexAll
Enrollment484 (estimated)
SponsorJohns Hopkins University
Academic / other
Locations6 sites (St. Petersburg, Florida and 5 other locations)
StatusRecruiting
StartedMarch 15, 2025
Main results expectedJune 15, 2028
Study endsJuly 15, 2029
Registry record updatedNovember 4, 2026
Trial IDNCT06151158 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are youth aged 12-19 who present to emergency departments with suicide-related concerns or who screen positive for serious suicidal ideation.

Probably not a fit

Patients with significant cognitive or developmental delays that hinder their ability to understand or use the interventions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effectiveness of two brief, evidence-based interventions aimed at preventing suicidal crises among youth aged 12-19 who present in emergency departments. The interventions include the Stanley Brown Safety Planning Intervention with Follow-up Contacts, which focuses on crisis de-escalation, and Interpersonal Psychotherapy for Adolescents Ultra Short Crisis Intervention, which addresses interpersonal issues contributing to suicidal thoughts. The research will take place in ethnically and racially diverse urban areas, including Philadelphia, Baltimore, and New York City, to ensure a broad representation of high-risk youth. The findings aim to inform future standards of care for suicidal adolescents in acute settings.

Why it matters

Potential benefit: If successful, this study could significantly reduce suicidal behavior among high-risk youth by identifying effective interventions for acute care settings.

How similar studies have gone: Other studies have shown promise in using similar interventions for suicide prevention, but this specific approach in acute care settings is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Suicide Risk During Acute Care Visit (At least one item must apply: Chief complaint of suicide-related concern, Active suicidal ideation endorsed in past 1 month on validated suicide screener, Suicidal behavior in the past 3 months on validated suicide screener, and/or Clinician indicated SI in past month or SA in past 3 months).
* Have access to a cellular phone with the ability to receive phone calls and text messages over the 12-month follow- up period
* Adolescent must be verbally fluent and can communicate, understand, and read in either English or Spanish
* Adolescent has been/will be discharged from a higher level of care (i.e. inpatient, day hospital, partial hospitalization program (PHP), or residential treatment program) and back in the community within 4 weeks of the acute care visit.

Exclusion Criteria:

* Significant cognitive or developmental delays that prevent understanding or using SPI+ or IPT-A-SCI (includes inability to communicate verbally)
* Altered mental status (acute psychosis, intoxication, or mania)
* Unable or unwilling to provide informed consent (adults), assent (minors), or permission (parents/caregivers)
* The services offered through the study are not in the best clinical interest of the patient (e.g., presenting problem requires a different level of care or treatment approach).

Where it's running

  • Johns Hopkins All Children's Hospital
    St. Petersburg, Florida, United States
    Recruiting
  • Johns Hopkins University
    Baltimore, Maryland, United States
    Recruiting
  • Columbia University Irving Medical Center (CUMC)
    New York, New York, United States
    Recruiting
  • Weill-Cornell Medicine
    New York, New York, United States
    Recruiting
  • University of North Carolina Medical Center
    Chapel Hill, North Carolina, United States
    Recruiting
  • Childrens Hospital of Philadelphia
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

  • Principal investigator: Holly C Wilcox, PhD — Johns Hopkins Bloomberg School of Public Health
  • Study coordinator: Holly C Wilcox, PhD
  • Email: hwilcox1@jhmi.edu
  • Phone: 410-370-0081

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.