Unilateral vs. Bilateral Resistance Training for Hypertension
Official title: Comparison of the Effects of Unilateral and Bilateral Resistance Training on Heart Rate Variability, Muscle Strength, and Functional Capacity in Individuals With Hypertension: A Randomized Controlled Trial
Run by Hacettepe University · NCT07751445 · Data updated 2026-11-12
This study tests whether exercising with one limb at a time or with both limbs at once can improve heart rate variability, strength, and daily function in adults with hypertension.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 75 Years |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | Hacettepe University Academic / other |
| Locations | 1 site (Tunceli) |
| Status | Recruiting |
| Started | June 22, 2026 |
| Main results expected | September 25, 2026 |
| Study ends | October 1, 2026 |
| Registry record updated | August 7, 2026 |
| Trial ID | NCT07751445 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 40–75 years with physician-confirmed hypertension who can safely participate in supervised resistance training.
✕Probably not a fit
Individuals with other cardiovascular diseases, neurological or psychiatric conditions, orthopedic limitations, or cognitive impairments may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial compares unilateral and bilateral resistance training against a non-exercise control in adults aged 40–75 with hypertension. Participants are randomly assigned to one of three groups to assess differences in heart rate variability, muscle strength, and functional capacity. The study uses supervised training sessions to ensure safety and consistent progression, with outcomes focused on autonomic function, physical fitness, and daily activity performance. Hypertension-related autonomic dysfunction and reduced muscle strength motivate the investigation of whether the scope of resistance training mass affects cardiovascular and functional adaptations.
Why it matters
Potential benefit: If successful, the approach could guide personalized exercise prescriptions to optimize cardiovascular health and functional ability in hypertension.
How similar studies have gone: Previous research supports resistance training for blood pressure control and fitness, but direct comparison of unilateral versus bilateral approaches in hypertension is limited yet plausible.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 40 to 75 years. * Physician-confirmed diagnosis of hypertension. * Medically stable and able to safely participate in a supervised resistance training program. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Presence of cardiovascular diseases other than hypertension. * Neurological disorders. * Psychiatric disorders. * Orthopedic conditions limiting participation in resistance exercise. * Any other systemic disease that may interfere with study participation. * Cognitive impairment or psychological conditions preventing completion of the assessments. * History of recent surgery or medical conditions contraindicating exercise. * Inability or unwillingness to comply with the study protocol.
Where it's running
-
Munzur University Faculty of Health Sciences
Tunceli, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ceyhun TOPCUOGLU, Dr.
- Email: ceyhuntopcuoglu1@gmail.com
- Phone: +90 535 653 51 37
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.