Understanding the tumor’s immune environment in pituitary tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the inflammatory and immune characteristics of pituitary tumors to identify biomarkers and molecular pathways that could guide immunotherapy and targeted therapies. Researchers will analyze tumor tissue and related data from adults undergoing surgical removal of pituitary tumors. The goal is to see how the tumor microenvironment correlates with aggressiveness and outcomes, without assigning an active treatment. No interventions are described; procedures follow standard surgical care and pathology assessment. Findings could inform future trials and biomarker-driven treatment decisions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* indication as per clinical practice and in agreement to current guidelines for surgical removal of the PitNET0;
* patient naïve to medical therapy before surgical removal of PitNET;
* Diagnosis of PitNET confirmed through the study pathological/histological;
* over 18 years of age;
* acceptance of participation in the study, by signing an informed consent.

Exclusion Criteria:

* History of medical therapy with analogs of somatostatin or dopamine agonist, previous the removal of the pituitary adenoma;
* history of radiotherapy of the head and neck region earlier than 10 years after resection of the adenoma pituitary;
* history of autoimmune diseases.

Where it's running

• Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC ENDOCRINOLOGIA
  Rome, Lazio, Italy Recruiting

Study contacts

• Principal investigator: Sabrina Chiloiro — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Sabrina Chiloiro
• Email: sabrina.chiloiro@policlinicogemelli.it
• Phone: +390630154440

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.