Investigating molecular differences in invasive pituitary tumors
Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions
This study is trying to find out what makes invasive pituitary tumors more aggressive by looking at tumor samples from patients and comparing their molecular differences.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06705036 on ClinicalTrials.gov |
What this trial studies
This observational study collects paired tumor samples from the intrasellar and cavernous sinus regions of 20 patients with invasive pituitary tumors. The samples are preserved for multi-omics analysis, including proteomics and transcriptomics, to identify molecular differences that may drive tumor aggressiveness. Imaging data from MRI and CT scans will assess tumor morphology and invasion, while in vitro experiments will validate key findings. The goal is to uncover biomarkers and pathways associated with tumor invasiveness and regional specificity.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-80 with invasive pituitary tumors involving the cavernous sinus.
Not a fit: Patients with non-invasive pituitary tumors or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of new therapeutic targets for invasive pituitary tumors.
How similar studies have performed: While similar studies have explored tumor biology, this specific approach combining multi-omics and imaging in pituitary tumors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Invasive pituitary tumors involving the cavernous sinus 2. Retrospective inclusion of patients who have signed informed consent forms for the donation of biological samples and health-related information 3. Age range: 18-80 years 4. Subjects are willing to participate in this study Exclusion Criteria: 1. Non-invasive pituitary tumors 2. Pregnant or breastfeeding 3. Other conditions deemed unsuitable for participation in this clinical trial as assessed by the physician
Where this trial is running
Shanghai, Shanghai Municipality
- Zhongshan Hospital Fudan University — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Tao Xie
- Email: xie.tao@zs-hospital.sh.cn
- Phone: +8613524281211
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.