Understanding the causes and effects of acute-on-chronic liver failure
Beobachtungsstudie für Die Charakterisierung Der Pathogenese Des Akut-auf-chronischen Leberversagens
This study looks at different aspects of acute-on-chronic liver failure to see how it affects patients with liver cirrhosis and improve treatment options for them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Johann Wolfgang Goethe University Hospital Academic / other |
| Locations | 1 site (Frankfurt, Hessen) |
| Trial ID | NCT04975490 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on characterizing the pathogenesis of acute-on-chronic liver failure (ACLF) through three distinct cohorts. The SAPIENT cohort examines the differences between ACLF and sepsis in patients with liver cirrhosis, while the PROACT cohort investigates portal venous biomarkers in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) procedures. The ELITE cohort aims to identify predictors of survival in ACLF patients receiving liver transplantation, with the goal of improving patient selection for this procedure. Biological samples will be collected for additional studies to further understand the condition.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with liver cirrhosis.
Not a fit: Patients with extrahepatic or metastatic malignancies, or those who refuse participation, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of ACLF, potentially enhancing survival rates for affected patients.
How similar studies have performed: While this study explores specific aspects of ACLF, similar observational studies have shown promise in understanding liver conditions, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Liver cirrhosis Exclusion Criteria: * extrahepatic and metastatic malignancy, * refusal for participation * decision of attending phycisian
Where this trial is running
Frankfurt, Hessen
- Translational Hepatology — Frankfurt, Hessen, Germany (Recruiting)
Study contacts
- Principal investigator: Jonel Trebicka, MD, PhD — Goethe University Hospital Frankfurt
- Study coordinator: Jonel Trebicka, MD, PhD
- Email: jonel.trebicka@kgu.de
- Phone: +4963014256
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.