Understanding resistant hypertension and its complex interactions

Resistant Hypertension An Open, Complicated ("Cum Plicare") or Complex ("Cum Plexus")

This study looks at how different body systems interact in people with resistant high blood pressure to better understand why some treatments don't work.

Quick facts

• Study type: Observational
• Enrollment: 80 (estimated)
• Ages: 18 Years to 85 Years
• Sex: All
• Sponsor: University of Campinas, Brazil (Academic / other)
• Locations: 1 site (Votuporanga, São Paulo)
• Trial ID: NCT06450327 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate resistant arterial hypertension (RAH) by examining the interplay between the autonomic nervous system, hemodynamic variables, and neuroimmune-endocrine systems. Researchers will utilize advanced cardiovascular autonomic modulation procedures to analyze heart rate variability and blood pressure variability. The study will involve participants who have been diagnosed with RAH and will assess various clinical alterations and their relationships with sympathetic nervous system activity. The goal is to provide a comprehensive understanding of the factors contributing to treatment resistance in hypertension.

Who should consider this trial

Good fit: Ideal candidates are men and women over 35 years old diagnosed with resistant arterial hypertension who have been under regular follow-up for at least six months.

Not a fit: Patients with heart failure, significant cardiovascular diseases, or other serious health conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for patients with resistant hypertension.

How similar studies have performed: While there have been studies on hypertension, this approach of integrating multiple systems in understanding resistant hypertension is relatively novel.

Eligibility criteria

Inclusion Criteria:

* men and women over 35 years of age diagnosed with resistant arterial hypertension (RH), in accordance with the latest international and national guidelines;
* be able to understand, verbalize and answer questions;
* agree to participate in the study and sign the Informed Consent Form;
* after clearly understanding it;
* be under regular follow-up at the UNICAMP Cardiovascular Pharmacology outpatient clinic for at least six months;
* have proven adherence to non-pharmacological and pharmacological treatment;
* women in the reproductive phase must be using a proven effective contraceptive method.

Exclusion Criteria:

* clinical history or clinical symptoms of heart failure;
* patients with dilated cardiomyopathies, valvular heart disease, pericardial disorders;
* patients with cerebrovascular disease or peripheral arterial disease, nephropathies, liver diseases, smoking, autoimmune diseases and use of illicit substances;
* any abnormal condition that may interfere with the results of the study or the health of the volunteer, as judged by the researcher;
* women who are pregnant or intend to become pregnant;
* current participation in another investigative study;
* major depression or other relevant psychiatric disorders.

Where this trial is running

Votuporanga, São Paulo

• Tatiane de Azevedo Rubio — Votuporanga, São Paulo, Brazil (Recruiting)

Study contacts

• Study coordinator: Tatiane de Azevedo Rubio

Conditions Hypertension; Resistant Hypertension; autonomic nervous system; resistant hypertension; arterial hypertension; refractory hypertension; baroreceptors