Understanding resistant hypertension and its complex interactions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate resistant arterial hypertension (RAH) by examining the interplay between the autonomic nervous system, hemodynamic variables, and neuroimmune-endocrine systems. Researchers will utilize advanced cardiovascular autonomic modulation procedures to analyze heart rate variability and blood pressure variability. The study will involve participants who have been diagnosed with RAH and will assess various clinical alterations and their relationships with sympathetic nervous system activity. The goal is to provide a comprehensive understanding of the factors contributing to treatment resistance in hypertension.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* men and women over 35 years of age diagnosed with resistant arterial hypertension (RH), in accordance with the latest international and national guidelines;
* be able to understand, verbalize and answer questions;
* agree to participate in the study and sign the Informed Consent Form;
* after clearly understanding it;
* be under regular follow-up at the UNICAMP Cardiovascular Pharmacology outpatient clinic for at least six months;
* have proven adherence to non-pharmacological and pharmacological treatment;
* women in the reproductive phase must be using a proven effective contraceptive method.

Exclusion Criteria:

* clinical history or clinical symptoms of heart failure;
* patients with dilated cardiomyopathies, valvular heart disease, pericardial disorders;
* patients with cerebrovascular disease or peripheral arterial disease, nephropathies, liver diseases, smoking, autoimmune diseases and use of illicit substances;
* any abnormal condition that may interfere with the results of the study or the health of the volunteer, as judged by the researcher;
* women who are pregnant or intend to become pregnant;
* current participation in another investigative study;
* major depression or other relevant psychiatric disorders.

Where it's running

• Tatiane de Azevedo Rubio
  Votuporanga, São Paulo, Brazil Recruiting

Study contacts

• Study coordinator: Tatiane de Azevedo Rubio
• Email: thatyazevedo@gmail.com
• Phone: +55(17)991422510

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.