Understanding locoregional recurrence in advanced colon cancer
A Translational Study for Locoregional Recurrence of T4 Colon Cancer
This study looks at how and why advanced colon cancer can come back in certain patients to see if new blood tests can help predict their outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Hsinchu) |
| Trial ID | NCT06958926 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the poor outcomes associated with locoregional recurrence in T4 colon cancer. It aims to explore the clinicopathology, metastatic mechanisms, and cancer biology of T4 colorectal cancer, particularly focusing on the hypothesis that peritoneal spreading may be a significant metastatic route. The study will analyze serum epigenetic alterations and cell-free DNA as potential prognostic markers for patients with stage II and III colon cancer who have undergone radical or palliative colectomy.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with colorectal cancer who are scheduled for radical or palliative colectomy.
Not a fit: Patients under 18 years old, pregnant individuals, those on peritoneal dialysis, or those unwilling to undergo colorectal surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of T4 colon cancer, potentially enhancing patient outcomes.
How similar studies have performed: While this study addresses a less explored area of T4 colon cancer, previous research has indicated that serum epigenetic alterations and cell-free DNA can serve as prognostic markers, suggesting some foundational success in related studies.
Eligibility criteria
Show full inclusion / exclusion criteria
* Inclusion Criteria: 1. Age ≥ 18 years old 2. Diagnosed as colorectal cancer 3. Undergo radical colectomy or palliative colectomy, not limited to minimally invasive surgery or open surgery * Exclusion Criteria: 1. Age\<18 years old 2. Pregnancy 3. Patients with peritoneal dialysis 4. Patients who are unwilling to undergo colorectal surgery
Where this trial is running
Hsinchu
- National Taiwan University Hospital Hsin-Chu branch — Hsinchu, Taiwan (Recruiting)
Study contacts
- Principal investigator: Yu-Tso Liao, MD, PhD — National Taiwan University Hospital Hsin-Chu Branch
- Study coordinator: Yu-Tso Liao, MD, PhD
- Email: G02386@hch.gov.tw
- Phone: 886-3667-7600
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.