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Using the Current Together After Cancer (CTAC) website to improve follow-up care for colorectal cancer survivors

A Pragmatic Randomized Controlled Trial to Evaluate the Effectiveness of an Intervention Called Current Together After Cancer (CTAC) to Promote Guideline-Concordant Colorectal Cancer Surveillance

Phase 3 Interventional SWOG Cancer Research Network · NCT07018869

This trial tests whether the CTAC website helps people with resected stage II or III colorectal cancer and a chosen adult supporter get recommended follow-up care that follows guidelines.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment1057 (estimated)
Ages18 Years and up
SexAll
SponsorSWOG Cancer Research Network Research network
Locations384 sites (Anchorage, Alaska and 383 other locations)
Trial IDNCT07018869 on ClinicalTrials.gov

What this trial studies

This phase III randomized trial compares access to an interactive CTAC intervention website versus a control website for patients with surgically resected stage II or III colorectal cancer. The primary outcome is receipt of guideline-concordant colorectal cancer surveillance at 12 months after registration, with patient-reported knowledge, self-efficacy, and satisfaction with supporter engagement measured at 3 and 16 months. The intervention actively involves an adult supporter chosen by the patient and includes online educational content aimed at improving surveillance management and communication. The study also includes mixed-methods process evaluation to identify implementation barriers and to explore how supporter participation relates to outcomes.

Who should consider this trial

Good fit: Adults with newly diagnosed, surgically resected stage II or III colorectal cancer who have an adult supporter willing to view the website with them and can access web-based content are ideal candidates.

Not a fit: Patients without an available adult supporter, those unable or unwilling to use online resources, or people with other cancer stages are unlikely to benefit from this intervention.

Why it matters

Potential benefit: If successful, CTAC could increase the number of colorectal cancer survivors receiving guideline-based surveillance and help detect recurrences earlier.

How similar studies have performed: Previous web-based and caregiver-supported educational interventions have shown mixed but promising results for improving follow-up care adherence and patient self-efficacy.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* PATIENTS:
* Patient participants must have newly diagnosed surgically resected, stage II or stage III colorectal cancer per the timing described below
* Patient participants must have an adult in their life who supports them in their colorectal cancer journey who they might be willing to invite to join them in viewing an educational website. This is determined via the question: "Do you have an adult in your life, such as a spouse/partner, family member or friend, who supports you with your colorectal cancer journey and may be willing to view a website with you? When we say, "supports you in your colorectal cancer journey", we mean things like, helping you keep and get to medical appointments, talking with you and/or your doctors about your cancer, or helping you make decisions about your cancer."

  * Those who respond "no" to the question above will be told that "Because this study is for patients and a supporter to view the website together, you are not eligible for this study, but there may be other studies you are eligible for in the future".
  * NOTE: The above question will be used to define "supporter" for purposes of this study. Examples of supporters include a spouse, partner, sibling, adult child, another family member, or friend.
  * NOTE: The supporter does not have to agree to participate in the study in order for the patient to be eligible for this study. Justification for requiring the enrolled patient to have a supporter (whether the supporter is invited or participates) is based on the study's underlying conceptual framework
* Patient participants must not have recurrent or metastatic (stage IV) colorectal cancer
* Patient participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the efficacy assessment of this intervention
* Patient participants must be registered within 90 - 180 days of surgical resection
* Patient participants must be ≥ 18 years of age at the time of registration/randomization. The lower cutoff of 18 was determined because the lower age range of patients that may be recruited to Southwest Oncology Group (SWOG) studies is 18
* Patient participants must have Zubrod performance status of 0-2
* Patient participants must be able to read English or Spanish since the website for the intervention and control arm are available in English and Spanish
* Patient participants must: 1) be able to complete Patient Reported Outcome (PRO) questionnaires in English or Spanish, and 2) agree to complete PROs at all scheduled timepoints
* Patient participants will be encouraged to provide an email address or cell phone number, if possible, for the purpose of being contacted by staff at the University of Michigan who will provide access to the educational website. For those who do not wish to provide or create an email address or a cell phone number, they may still participate with alternate methods
* Patient participants must not be enrolled or be planning to enroll in a clinical trial of investigational treatment that includes imaging and/or laboratory monitoring for the duration of this trial

  * NOTE: Patient participants are allowed to be co-enrolled on other non-treatment clinical trials
* SUPPORTER PARTICIPANT:
* Supporter participants must be ≥ 18 years of age at the time of registration/randomization
* Supporter participants must be able to read English or Spanish since the educational website is available in English and Spanish
* Supporter participants must have been identified by the patient as a person who may be willing to join them in reviewing the educational website
* PATIENT AND SUPPORTER:
* NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

  * Patient and supporter participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. This protocol does not permit use of Legally Authorized Representative

Where this trial is running

Anchorage, Alaska and 383 other locations

+334 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Colorectal Cancer Stage IIColorectal Cancer Stage III
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.