Understanding impulsivity in Parkinson's patients with deep brain stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This experimental study aims to investigate the mechanisms behind increased impulsivity in some Parkinson's disease patients who undergo deep brain stimulation (DBS) of the subthalamic nucleus. Participants will engage in decision-making tasks while their DBS devices are toggled on and off, allowing researchers to observe the effects on brain activity through magnetoencephalography (MEG). The study seeks to identify the network effects of DBS and explore alternative stimulation settings that may reduce impulsivity. By analyzing these interactions, the research hopes to provide insights into optimizing DBS for better patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged 18 years or above.
* Diagnosed with Parkinson's disease who have required implanted STN electrodes for DBS in addition to their dopamine replacement therapy.
* Diagnosed with or without (control group) impulse control disorders since the diagnosis of Parkinson's Disease.
* Participant willing and able to sit in the MEG scanner and follow instructions.
* Participant willing and able to delay their morning dose of dopamine replacement therapy for up to four hours (180 minutes experimental time + journey time).

Exclusion Criteria:

* Patients with extreme language barrier that cannot understand the purpose or instructions of the study despite the use of an interpreter.
* Other implanted medical devices that may cause artefacts during MEG recordings.
* Participants with a history of co-morbid neurological disorders.
* Participant enrolled onto another clinical trial related to a neurological disorder (including Parkinson's disease) that may interfere with the results of this study.
* Participants who are unable to sit still in a MEG scanner for the duration of this experiment e.g. patients with chronic pain or osteoarthritis. This will be assessed with their primary clinician

Where it's running

• John Radcliffe Hospital
  Oxford, United Kingdom Recruiting

Study contacts

• Study coordinator: John Eraifej, BSc MBChB MRCS
• Email: john.eraifej@ndcn.ox.ac.uk
• Phone: 01865222763

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.