Understanding immune system activation in patients with chronic kidney disease on dialysis
Activation of the Contact System and the Immune System in Patients With Chronic Kidney
This study looks at how the immune system works in people with chronic kidney disease on dialysis to see why they are more likely to get serious infections.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Odense University Hospital Academic / other |
| Locations | 1 site (Odense) |
| Trial ID | NCT05266092 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the immune response and contact system activation in patients with chronic kidney disease who are undergoing hemodialysis. It aims to explore the heightened mortality rates associated with bloodstream infections, particularly those caused by Staphylococcus aureus, and how hemodialysis may compromise the immune system's ability to combat these infections. By analyzing blood samples from patients, the study seeks to identify key factors that contribute to the increased susceptibility to infections in this population.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years with chronic kidney disease undergoing hemodialysis or peritoneal dialysis.
Not a fit: Patients with acute kidney disease or those not undergoing dialysis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing infections and reducing mortality in patients with chronic kidney disease on dialysis.
How similar studies have performed: While similar studies have explored immune responses in chronic kidney disease, this specific focus on hemodialysis patients and their susceptibility to S. aureus infections is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Participants with chronic kidney disease undergoing hemodialysis Inclusion criteria * Age \>18 years * Chronic kidney disease * Hemodialysis Exclusion criteria: \- Acute kidney disease Participants with chronic kidney disease, not in dialysis Inclusion criteria * Age \>18 years * Chronic kidney disease (eGFR from \<15 to 44) Exclusion criteria: * Acute kidney disease * Hemodialysis * Peritoneal dialysis Participants with chronic kidney disease undergoing peritoneal dialysis Inclusion criteria * Age \>18 years * Chronic kidney disease * Peritoneal dialysis Exclusion criteria: \- Acute kidney disease Healthy volunteers Inclusion criteria * Age \>18 years * Blooddonors Exclusion criteria: \- NA
Where this trial is running
Odense
- Odense University Hospital — Odense, Denmark (Recruiting)
Study contacts
- Study coordinator: Katrine Pilely, PhD
- Email: kapi@sdu.dk
- Phone: 0045 20963328
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.