Understanding how aging affects chronic inflammation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enroll healthy individuals aged 18-35 and those 65 years and older to investigate the health of immune cells in the blood and their role in chronic inflammation as we age. Participants will undergo a screening visit followed by a second visit that includes an oral glucose tolerance test, blood draws, and leg strength and exercise tests. The goal is to uncover the relationship between immune cell function and inflammation, which may lead to better therapies for managing chronic inflammation in aging populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 - 35y; 65y and older
2. BMI: \<30 kg/m2
3. Ability to sign informed consent
4. For older participant group: Clinical Frailty Scale score \< 3 and Mini-Cog score \> 3
5. Good general medical health, ambulatory and in independent living setting

Exclusion Criteria:

* History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)
* History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted)
* History of kidney disease or failure (CKD \> stage 4)
* History of vascular disease
* Uncontrolled hypertension - Elevated systolic pressure \>150 or a diastolic blood pressure \> 100
* Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
* Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted)
* Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment
* Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C
* History of stroke with motor disability
* A recent history (\<12 months) of GI bleed
* History of liver disease or AST/ALT 2 times above the normal limit
* History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
* Current smokers or current tobacco use
* Current pregnancy as determined by positive pregnancy test
* Any staff members who report directly to the principal investigators.

Where it's running

• The University of Utah
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Micah Drummond — The University of Utah
• Study coordinator: Micah Drummond, PhD
• Email: micah.drummond@hsc.utah.edu
• Phone: 801-213-2737

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.