Understanding the connection between obesity and liver inflammation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between inflammation in adipose tissue and the abnormal fat deposition around the liver in individuals with obesity. It focuses on how these factors influence liver function and insulin resistance, particularly in patients undergoing gastric bypass surgery. By analyzing data from participants with confirmed liver fibrosis, the study seeks to provide insights into the mechanisms linking obesity and liver health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Undergoing gastric bypass surgery
* Confirmed AUROC F=0 or F\>2 liver fibrosis
* Age 30-70 years
* BMI greater than 40 kg/m2
* Negative pregnancy test (female only)
* Lab Values: Normal TSH

Exclusion Criteria:

* Autoimmune diseases
* Hepatitis B or C positive
* Heavy alcohol use
* Active smoking history
* Active cancer history
* History of asthma
* History of COPD
* Taking Plavix or Coumadin
* Blood donation within past 2 months
* Glucocorticoid Therapy
* Taking antihistamine on regular basis

Where it's running

• Mayo Clinic in Arizona
  Scottsdale, Arizona, United States Recruiting

Study contacts

• Principal investigator: Elena Anna O De Filippis — Mayo Clinic
• Study coordinator: Keegan M Stewart
• Email: stewart.keegan@mayo.edu
• Phone: 480-301-4164

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Multiple under-the-skin injections of B1344 for adults with NAFLD and NASH

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  Recruiting Phase 1 Tasly Biopharmaceuticals Co., Ltd. · Beijing, Beijing Municipality and 4 other locations · NCT07128797

• Low-impact laparoscopy for sleeve gastrectomy in adults with obesity

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• Tranexamic acid to reduce bleeding in sleeve gastrectomy and mini gastric bypass

  This trial will test whether giving tranexamic acid before laparoscopic sleeve gastrectomy or mini gastric bypass reduces bleeding in adults with morbid obesity.

  Recruiting Phase 4 Patel Hospital, Pakistan · Karachi, Sindh · NCT07098780

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.