Understanding how aging affects blood vessel health and heart disease
Cellular and Molecular Mechanisms of Vascular Senescence and atherosclerotIC Plaque Vulnerability: the TelOmere-mitochondRIa Cross-tAlk Study
Niguarda Hospital · NCT06313645
This study looks at how getting older affects blood vessel health and heart disease in people with different heart conditions to find ways to improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Niguarda Hospital (other) |
| Locations | 1 site (Milan, Lombardy) |
| Trial ID | NCT06313645 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of vascular senescence and DNA damage in the development of coronary artery disease. It aims to explore how chronological aging and environmental factors contribute to vascular deterioration and atherosclerosis. By analyzing biomarkers related to DNA damage and cellular senescence, the study seeks to identify potential therapeutic targets to mitigate the effects of vascular aging. Participants will include patients with various forms of acute coronary syndromes and stable angina.
Who should consider this trial
Good fit: Ideal candidates for this study are patients experiencing acute coronary syndromes or stable angina.
Not a fit: Patients with severe conditions such as cardiac shock, congestive heart failure, or active cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new strategies for preventing or treating coronary artery disease by targeting the mechanisms of vascular aging.
How similar studies have performed: Other studies have shown promising results in understanding the mechanisms of vascular aging and its impact on heart disease, suggesting that this approach is both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with acute coronary syndromes (unstable angina, non-ST segment elevation myocardial infarction (NSTEMI), ST segment elevation myocardial infarction (STEMI)) * stable angina * non-angiographically significant coronary diseases recovered for elective diagnostic or interventional procedures Exclusion Criteria: * cardiac shock * congestive heart failure * end stage renal diseases * coronary artery bypass graft * active cancer
Where this trial is running
Milan, Lombardy
- ASST GOM Niguarda — Milan, Lombardy, Italy (RECRUITING)
Study contacts
- Study coordinator: Jonica Campolo, MSc
- Email: jonica.campolo@ospedaleniguarda.it
- Phone: +39026444
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Artery Disease, Vascular senescence, Genetic instability, Mitochondrial deregulation, Coronary syndrome