Understanding how a wrist fracture heals and why some people develop long-lasting pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort follows adults with recent distal radius fractures and a smaller group with chronic CRPS to explore biological and neurophysiological factors that influence recovery. Researchers will collect genetic data, blood biomarkers, wearable autonomic signals, and functional MRI to study body representation in the brain after injury. The goal is to identify early indicators that distinguish those at risk for chronic pain and CRPS, enabling targeted support in the future. The study plans to recruit about 250 participants over four years across Cambridge-area sites. Analyses will focus on linking multi-domain phenotypes with long-term outcomes to generate new hypotheses about pain mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Distal radius fracture (DRF) within past 6 weeks 18 and older Willing and competent to complete the informed consent process

Exclusion Criteria:

Inability to understand the informed consent process (Language, competence) Multiple trauma Significant neurological disease (multiple sclerosis, previous traumatic brain injury, previous stroke or cerebral haemorrhage and substantial tremor - including Parkinson's, significant resting tremor, or other aetiology) Amputation or medical confirmation of unilateral sensory deficit

Where it's running

• Addenbrooke's Hospital
  Cambridge, Cambridgeshire, United Kingdom Recruiting

Study contacts

• Study coordinator: Neal Chauhan, MBBS
• Email: neal.chauhan@nhs.net
• Phone: 01223 216182

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Wrist Injury Strengthening Exercise added to usual care for improving pain and function after a wrist fracture

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• Effects of whirlpool and contrast baths on pain in patients with complex regional pain syndrome after wrist fractures

  This study is testing whether whirlpool and contrast baths can help reduce pain and improve function in adults with complex regional pain syndrome after a wrist fracture.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar, Afyonkarahisar · NCT06769373

• Effects of a high CBD cannabis extract on pain in Complex Regional Pain Syndrome

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• Using low-dose naltrexone to relieve pain in complex regional pain syndrome

  This study is testing if low-dose naltrexone can help people with complex regional pain syndrome feel less pain.

  Recruiting Stanford University · Palo Alto, California · NCT02502162

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.