Using low-dose naltrexone to relieve pain in complex regional pain syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of low-dose naltrexone (LDN) in alleviating symptoms of complex regional pain syndrome (CRPS). Participants will be randomly assigned to receive either LDN or a placebo over several weeks. They will attend in-person or virtual visits and complete questionnaires to assess their symptoms and overall well-being. The goal is to determine if LDN can provide significant pain relief for individuals suffering from CRPS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Upper and/or lower extremity CRPS
* On stable treatment for 1 month
* CRPS for at least 1 year
* Meet the Budapest criteria for CRPS at time of the study.

Exclusion Criteria:

* Any known allergy to naltrexone or naloxone
* Use of prescription opioid analgesics or illegal opioid use
* Current or planned pregnancy.

Where it's running

• Stanford University
  Palo Alto, California, United States Recruiting

Study contacts

• Principal investigator: Sean Mackey, MD, PhD — Stanford University
• Study coordinator: Birute Gedrimaite
• Email: birute@stanford.edu
• Phone: (650) 497-0485

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.