Understanding hemorrhage subtypes in perimesencephalic SAH and basilar artery perforator aneurysms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects baseline imaging and patient-reported outcomes to describe the prevalence and clinical impact of hemorrhagic subtypes in perimesencephalic subarachnoid hemorrhage. Participants are adults with non-traumatic pmSAH (or pmSAH with limited adjacent blood) who provide informed consent and complete the EQ-5D questionnaire. The study analyzes PROM data alongside imaging findings to explore links between vascular lesions such as basilar artery perforator aneurysms and functional outcomes. No interventional treatment is performed; the focus is on characterization and correlation of imaging features with patient-reported quality of life. Results may improve understanding of pmSAH prognosis and guide future research on targeted management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged ≥18 years with a non-traumatic pmSAH or limited additional blood in adjacent cisterns (pmSAH "plus")
* Cross-sectional imaging at baseline (CT or MRI)
* Written informed consent for study participation was obtained.

Exclusion Criteria:

* Presence of documented written or verbal refusal
* pmSAH patients with a presumed traumatic source
* Saccular/fusiform aneurysm of the main arteries of the posterior circulation (e.g. V4, AICA, PICA, basilar trunk, basilar tip)
* pmSAH patients with a shunting lesion in the vertebrobasilar territory (i.e. brain AVM, brain/spine AVF)
* pmSAH patients with a cavernous malformation in the posterior fossa
* Basilar artery perforator aneurysm group (BAPA group):
* Aneurysm arising from the basilar artery trunk adjacent to a perforating branch but not involving a perforating artery (Satti Type 1)
* Flow-related BAPA (i.e. AVM, AVF)
* Severely impaired renal function defined as KDIGO grade 4 (GFR \<30 mL/min/1.73 m2)
* Pregnancy or suspected pregnancy
* Known adverse events to iodinated contrast media

Where it's running

• Inselspital, University Hospital Bern
  Bern, Switzerland Recruiting

Study contacts

• Study coordinator: Tomas Dobrocky, MD
• Email: tomas.dobrocky@insel.ch
• Phone: +41 31 632 13 77

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.