Understanding heart failure through detailed patient profiles and molecular profiling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects comprehensive clinical data and deep molecular data from participants with heart failure to identify molecular patterns associated with disease onset and progression. It uses multi-omics approaches such as transcriptomics, epigenomics, and proteomics, along with imaging, hemodynamic data, and biomarker analyses, to create deep phenotypes. The goal is to find biomarkers that predict progression and to identify potential new therapeutic targets for future treatment strategies. Participants will undergo follow-up assessments and sample collection as part of routine clinical evaluation. The study is led by the University of Zurich at the University Hospital Zurich, with no listed collaborators.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA

* Female and Male, age ≥18 years at screening.
* Diagnosis of Heart Failure according to ESC Heart Failure Guidelines
* Ability to understand the requirements of the study and to provide informed consent.
* Willingness to undergo follow-up.

EXCLUSION CRITERIA

Patients will be excluded if they meet any of the following conditions:

* Active malignancy or history of cancer with ongoing treatment (e.g., chemotherapy, radiotherapy, immunotherapy).
* Autoimmune or systemic inflammatory diseases.
* Concomitant infections, including acute systemic infections (e.g., sepsis, pneumonia) or chronic infections with systemic impact (e.g., HIV, hepatitis B/C with elevated transaminases).

Other exclusion criteria:

* Age\<18 years old
* Inability to provide written informed consent

Where it's running

• University Hospital of Zurich
  Zurich, Switzerland Recruiting

Study contacts

• Principal investigator: Jan A Kleeberger, MD — Universitätsspital Zürich
• Study coordinator: Jan A Kleeberger, MD
• Email: janalphard.kleeberger@usz.ch
• Phone: +41763220376

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Voice-based detection of heart failure deterioration using Noah Labs Vox

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.