Understanding heart disease causes in South Asians in America
Mediators of Atherosclerosis in South Asians Living in America
This study is trying to find out what causes heart disease in South Asians living in America to better understand their unique health risks.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2314 (estimated) |
| Ages | 40 Years to 84 Years |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 3 sites (San Francisco, California and 2 other locations) |
| Trial ID | NCT01207167 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on South Asian individuals living in the United States, who have high rates of cardiovascular disease that are not fully explained by traditional risk factors. The research aims to establish a longitudinal study across three centers to identify risk factors associated with subclinical atherosclerosis and the incidence of cardiovascular disease in this population. By comparing these findings with other ethnic groups in the U.S., the study seeks to enhance understanding of the unique cardiovascular risks faced by South Asians.
Who should consider this trial
Good fit: Ideal candidates are South Asian individuals aged 40 to 84 with at least three grandparents from India, Pakistan, Bangladesh, Nepal, or Sri Lanka.
Not a fit: Patients with a history of significant cardiovascular events or procedures, or those with serious medical conditions affecting life expectancy, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for cardiovascular diseases in South Asian populations.
How similar studies have performed: While there is limited longitudinal research specifically targeting South Asians, studies on cardiovascular risk factors in diverse populations have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka * age between 40 and 84 years. Exclusion Criteria: * Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin) * Current atrial fibrillation * Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries) * Active treatment for cancer * Life expectancy less than 5 years due to serious medical illness * Impaired cognitive ability as judged by the reviewer * Plans to move out of the study region in next 5 years * Weight greater than 300 pounds * Living in a nursing home or on a waiting list * Unable to speak/read/write English, Hindi, Urdu, or Bangla
Where this trial is running
San Francisco, California and 2 other locations
- University of California, San Francisco — San Francisco, California, United States (Active_not_recruiting)
- Northwestern University — Chicago, Illinois, United States (Recruiting)
- New York University — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Alka Kanaya, MD — University of California, San Francisco
- Study coordinator: Alka Kanaya, MD
- Email: alka.kanaya@ucsf.edu
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.