Understanding Healthy Obesity and Its Risks
Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?
ETH Zurich · NCT06799897
This study looks at what makes some obese people healthy while others develop health problems, to see if understanding these differences can help improve their health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | ETH Zurich (other) |
| Locations | 1 site (Baden) |
| Trial ID | NCT06799897 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the factors that differentiate metabolically healthy obese individuals from those who develop metabolic diseases. It will involve a cross-sectional comparison to identify distinguishing characteristics and a longitudinal approach to track changes over time. The researchers hypothesize that alterations in adipose tissue regulation and composition contribute to the transition from healthy to unhealthy obesity. The findings could lead to new diagnostic tools for personalized risk assessment and innovative strategies to enhance metabolic health.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 60 with a BMI between 30 and 50 who are metabolically healthy.
Not a fit: Patients with significant metabolic diseases or those who have undergone bariatric surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights that help prevent the progression of obesity-related metabolic diseases.
How similar studies have performed: While the concept of healthy obesity is being explored, this study's specific approach to understanding its natural course is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed Informed Consent Form * Age between 18 and 60 years * BMI 30-50 kg/m2 * Knowledge of German, which requires sufficient written and allow oral patient education Inclusion criteria for initially healthy group * Blood pressure \< 140/90 mmHg * Normal glucose metabolism * HbA1c \< 6.5 % * Fasting Glucose \< 7.0 mmol/l * Normal lipid metabolism o LDL-cholesterol \< 5.0 mmol/l * ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference) * TG \> 1.7 mmol/l * HDL-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female) * Fasting glucose ≥ 5.6 mmol/l * BP ≥ 130/85 mmHg Exclusion Criteria: * Pregnancy * Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies * History of or planned bariatric operation * Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases) * Active Malignant tumor (\<2a remission)
Where this trial is running
Baden
- dTIP / ETH Zürich — Baden, Switzerland (RECRUITING)
Study contacts
- Study coordinator: Jörg Goldhahn, Prof.
- Email: jgoldhahn@ethz.ch
- Phone: 044 633 70 54
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy Obesity, Metabolically, Obesity, Healthy