Understanding Healthy Obesity and Its Risks

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the factors that differentiate metabolically healthy obese individuals from those who develop metabolic diseases. It will involve a cross-sectional comparison to identify distinguishing characteristics and a longitudinal approach to track changes over time. The researchers hypothesize that alterations in adipose tissue regulation and composition contribute to the transition from healthy to unhealthy obesity. The findings could lead to new diagnostic tools for personalized risk assessment and innovative strategies to enhance metabolic health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed Informed Consent Form
* Age between 18 and 60 years
* BMI 30-50 kg/m2
* Knowledge of German, which requires sufficient written and allow oral patient education

Inclusion criteria for initially healthy group

* Blood pressure \< 140/90 mmHg
* Normal glucose metabolism

  * HbA1c \< 6.5 %
  * Fasting Glucose \< 7.0 mmol/l
* Normal lipid metabolism

  o LDL-cholesterol \< 5.0 mmol/l
* ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference)
* TG \> 1.7 mmol/l
* HDL-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female)
* Fasting glucose ≥ 5.6 mmol/l
* BP ≥ 130/85 mmHg

Exclusion Criteria:

* Pregnancy
* Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies
* History of or planned bariatric operation
* Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases)
* Active Malignant tumor (\<2a remission)

Where it's running

• dTIP / ETH Zürich
  Baden, Switzerland Recruiting

Study contacts

• Study coordinator: Jörg Goldhahn, Prof.
• Email: jgoldhahn@ethz.ch
• Phone: 044 633 70 54

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.